基因在细胞核中的位置对转录调控的影响。
The impact of gene location in the nucleus on transcriptional regulation.
作者信息
Dillon Niall
机构信息
Gene Regulation and Chromatin Group, MRC Clinical Sciences Centre, Faculty of Medicine, Imperial College, Hammersmith Campus, Du Cane Road, London W12ONN, UK.
出版信息
Dev Cell. 2008 Aug;15(2):182-6. doi: 10.1016/j.devcel.2008.07.013.
Localization of genes to different parts of the nucleus has the potential to promote activation or silencing of transcription. Current evidence suggests that these effects are mediated by specific molecular interactions between genes and nuclear structures rather than by partitioning of the nucleus into discrete compartments. A growing body of data identifies the nuclear envelope as a major organizer of location-specific interactions for both silent and active genes.
基因定位于细胞核的不同区域有可能促进转录的激活或沉默。目前的证据表明，这些效应是由基因与核结构之间的特定分子相互作用介导的，而不是由细胞核划分为离散的区室介导的。越来越多的数据表明，核膜是沉默基因和活跃基因位置特异性相互作用的主要组织者。
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