González-Arriagada Wilfredo Alejandro, Santos-Silva Alan Roger, Ito Fabio Augusto, Vargas Pablo Agustin, Lopes Marcio Ajudarte
Oral Diagnosis Department, Semiology and Oral Pathology, Piracicaba Dental School, State University of Campinas, Piracicaba, Brazil.
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2011 Apr;111(4):482-5. doi: 10.1016/j.tripleo.2010.10.022. Epub 2011 Feb 3.
Calcifications in mucoepidermoid carcinoma (MEC) of the salivary glands are considered to be exceptionally rare and are often associated with high-grade tumors. This study reviewed 30 cases of MECs to access the frequency of calcifications and the clinical profile of the patients and histopathologic aspects of the tumors. In total, 6 cases of calcifications (20%) were identified. Five patients were women and 1 was a man, patients' ages ranged from 22 to 69 years old, and calcifications were found in conventional and clear cell-type MECs. Areas of calcification showed positivity for periodic acid-Schiff and mucicarmine, supporting the hypothesis that they originate from the precipitation of mucous secretion. The presence of calcifications in MECs was independent of the histologic grade of the tumors and the histopathologic variants. Calcifications in salivary MECs may not be as rare as previously mentioned in the literature and may be not associated with high-grade tumors.
涎腺黏液表皮样癌（MEC）中的钙化被认为极为罕见，且常与高级别肿瘤相关。本研究回顾了30例MEC病例，以了解钙化的发生率、患者的临床特征以及肿瘤的组织病理学特征。总共识别出6例钙化病例（20%）。5例患者为女性，1例为男性，患者年龄在22至69岁之间，钙化见于传统型和透明细胞型MEC。钙化区域对过碘酸希夫反应和黏液卡红染色呈阳性，支持其起源于黏液分泌沉淀的假说。MEC中钙化的存在与肿瘤的组织学分级和组织病理学亚型无关。涎腺MEC中的钙化可能并不像文献中先前所述的那样罕见，且可能与高级别肿瘤无关。
