Department of Pathology, University of Erlangen, Erlangen, Germany.
Histopathology. 2011 Mar;58(4):557-70. doi: 10.1111/j.1365-2559.2011.03777.x. Epub 2011 Mar 3.
To correlate World Health Organization (WHO) grade, patient's outcome and presence of t(11;19) to histological tumour variants in 40 well-characterized mucoepidermoid carcinomas (MECs).
MECs were classified as 'classical' based on the presence of equal proportions of the three cell types or the dominance (≥50%) of mucous cells together with at least one other cell type, and as 'variant' if composed of ≥80% of a single non-mucous cell type. Classical MECs were more common (n=23). Variant MECs had predominant squamoid (n=9), eosinophilic (n=5) or clear cell (n=3) morphology. Twenty-seven tumours were WHO grade 1, three grade 2 and ten grade 3. The t(11;19) was detected in 82%, 35% and 0% of classical MEC, variant MEC and non-MEC, respectively. Classical MECs were associated significantly with age ≤60 years (P<0.001), grade 1 (P<0.001) and t(11;19) (P=0.003). Short overall survival was associated significantly with age >60 years (P=0.001) and Union for International Cancer Control (UICC) stage >I (P=0.031), residual tumour (P<0.001), tumour grade >1 (P=0.001) and squamoid variant (P=0.002) in Kaplan-Meier analysis.
The results underscore the great histological diversity of MEC, the reproducibility of the WHO grading criteria and the value of histological subtypes as an additional prognostic factor.
在 40 例经过充分特征描述的黏液表皮样癌（MEC）中，将世界卫生组织（WHO）分级、患者结局和 t（11；19）与组织学肿瘤变体相关联。
MEC 根据三种细胞类型的比例相等或黏液细胞占主导地位（≥50%）并至少有另一种细胞类型来分类为“经典型”，如果由≥80%的单一非黏液细胞类型组成，则分类为“变体型”。经典型 MEC 更为常见（n=23）。变体 MEC 具有明显的鳞状（n=9）、嗜酸性粒细胞（n=5）或透明细胞（n=3）形态。27 个肿瘤为 WHO 分级 1 级，3 个为 2 级，10 个为 3 级。t（11；19）在经典型 MEC、变体型 MEC 和非 MEC 中的检出率分别为 82%、35%和 0%。经典型 MEC 与年龄≤60 岁（P<0.001）、分级 1（P<0.001）和 t（11；19）（P=0.003）显著相关。总生存时间较短与年龄>60 岁（P=0.001）和国际抗癌联盟（UICC）分期>1 期（P=0.031）、残余肿瘤（P<0.001）、肿瘤分级>1 级（P=0.001）和鳞状变体（P=0.002）显著相关。
这些结果强调了 MEC 具有很大的组织学多样性，WHO 分级标准具有可重复性，并且组织学亚型作为附加预后因素具有价值。
