Department of Rheumatology, St Olav's Hospital, Trondheim University Hospital, Bevegelsessenteret, N-7006 Trondheim, Norway.
Rheumatology (Oxford). 2011 Jun;50(6):1162-7. doi: 10.1093/rheumatology/keq458. Epub 2011 Feb 3.
To compare fertility rates in women with RA, other chronic arthritides (OCAs) and JIA with reference women from the general population.
Each woman from a Norwegian patient registry was matched by year of birth with 100 reference women randomly selected from the National Population Registry. Data linkage of patients and references with the Medical Birth Registry of Norway (MBRN) identified all offspring in patients and references until October 2007, and indirectly also nulliparous (childless) women. Groups were compared with Mann-Whitney U-test for continuous variables and chi-squared tests for categorical variables. Poisson regression analysis was applied to calculate relative fertility rates in the diagnostic groups vs references.
Among 631 patients 849 children were registered in MBRN. Of these, 289 children (34.0%) were born after time of diagnosis vs 44.3% in references. Altogether, 206 of 631 patients (32.6%) were nulliparous vs 26.4% in references (P < 0.001). Among RA patients, 28.4% (96 of 338) were nulliparous vs 24.5% in references (P = 0.09), 30.7% (67 of 218) in OCA patients vs 24.5% in references (P = 0.03) and 57.3% (43 of 75) in JIA patients vs 40.9% in references (P = 0.004). Adjusted relative fertility rates in RA, OCA and JIA after diagnosis were 0.88, 0.84 and 0.84, respectively, compared with references.
A higher proportion of women with chronic inflammatory arthritides were nulliparous compared with references, and relative fertility rates were reduced in all patient groups.
将类风湿关节炎（RA）、其他慢性关节炎（OCAs）和幼年特发性关节炎（JIA）患者的生育率与普通人群中的参考女性进行比较。
从挪威患者登记处的每位女性，按照出生年份与从国家人口登记处随机抽取的 100 名参考女性进行匹配。患者和参考女性与挪威医学出生登记处（MBRN）的数据链接，确定了患者和参考女性所有的子女，直至 2007 年 10 月，并且间接地确定了未生育（无子）的女性。使用 Mann-Whitney U 检验比较连续变量，使用卡方检验比较分类变量。应用泊松回归分析计算诊断组与参考组的相对生育率。
在 631 名患者中，有 849 名子女在 MBRN 中注册。其中，289 名（34.0%）子女在诊断后出生，而参考组中为 44.3%。共有 631 名患者中的 206 名（32.6%）未生育，而参考组中为 26.4%（P < 0.001）。在 RA 患者中，28.4%（338 名中的 96 名）未生育，而参考组中为 24.5%（P = 0.09），30.7%（218 名中的 67 名）在 OCA 患者中，而参考组中为 24.5%（P = 0.03），57.3%（75 名中的 43 名）在 JIA 患者中，而参考组中为 40.9%（P = 0.004）。RA、OCA 和 JIA 诊断后的调整相对生育率分别为 0.88、0.84 和 0.84，与参考组相比。
与参考组相比，患有慢性炎症性关节炎的女性未生育的比例更高，并且所有患者组的相对生育率都降低了。
