Buschard K
Acta Pathol Microbiol Scand C. 1978 Feb;86(1):29-32. doi: 10.1111/j.1699-0463.1978.tb02553.x.
The study describes passive transfer of diabetes mellitus by transplantation of spleen cells from donor mice infected with a diabetogenic encephalomyocarditis virus. Inbred normal C57 mice were used as both donors and recipients, and other recipients were C57 athymic, nude mice. Transplants were made in two series after 12 and 22 days duration of infection of the donors, respectively. All recipients became diabetic. The possibility of virus transfer with the spleen cell transplant is discussed, and found to be highly improbable. The fact that passive cellular transfer can be effected points to a decisive significance of the thymus dependent lymphocyte system in the pathogenesis of the primary diabetes.
该研究描述了通过移植来自感染致糖尿病性脑心肌炎病毒的供体小鼠的脾细胞来实现糖尿病的被动转移。近交系正常C57小鼠用作供体和受体，其他受体为C57无胸腺裸鼠。分别在供体感染12天和22天后进行了两个系列的移植。所有受体均患糖尿病。文中讨论了病毒随脾细胞移植转移的可能性，发现这种可能性极小。被动细胞转移能够实现这一事实表明，胸腺依赖性淋巴细胞系统在原发性糖尿病的发病机制中具有决定性意义。
