Beattie G, Lannom R, Lipsick J, Kaplan N O, Osler A G
Diabetes. 1980 Feb;29(2):146-50. doi: 10.2337/diab.29.2.146.
Spleen cells from conventional BALB/c or athymic mice with streptozotocin (SZ)-induced hyperglycemia failed to raise blood sugar levels when injected into athymic or thymus-sufficient recipients. Passive transfer efforts were unsuccessful despite variations in donor-recipient pairs with respect to age, thymic function, or time after sensitization of donor mice. Athymic mice develop hyperglycemia following SZ but fail to mount an inflammatory lymphocyte infiltration. In contrast, the heterozygotes show a marked cellular response, which seems to follow the onset of hyperglycemia. The injection of spleen cells from thymus-sufficient mice to athymic recipients confers immunologic competence on the latter as tested by antibody formation to sheep erythrocytes.
来自常规BALB/c小鼠或无胸腺小鼠且患有链脲佐菌素（SZ）诱导的高血糖症的脾细胞，在注射到无胸腺或胸腺功能正常的受体小鼠体内后，未能提高血糖水平。尽管在供体-受体配对中，供体小鼠的年龄、胸腺功能或致敏时间有所不同，但被动转移实验均未成功。无胸腺小鼠在注射链脲佐菌素后会出现高血糖症，但不会发生炎症性淋巴细胞浸润。相比之下，杂合子表现出明显的细胞反应，这种反应似乎随着高血糖症的出现而发生。将胸腺功能正常的小鼠的脾细胞注射到无胸腺受体小鼠体内后，通过检测对绵羊红细胞的抗体形成发现，后者获得了免疫能力。
