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用脾细胞进行链脲佐菌素诱导的糖尿病的被动转移。对正常和无胸腺裸鼠进行同基因和异基因转移的研究。

Passive transfer of streptozotocin induced diabetes mellitus with spleen cells. Studies of synogeneic and allogeneic transfer to normal and athymic nude mice.

作者信息

Buschard K, Rygaard J

出版信息

Acta Pathol Microbiol Scand C. 1977 Dec;85C(6):469-72. doi: 10.1111/j.1699-0463.1977.tb03670.x.

DOI:10.1111/j.1699-0463.1977.tb03670.x
PMID:305189
Abstract

This study shows passive transfer of streptozotocin induced diabetes mellitus in mice. Transplants of spleen cells from BALB/c mice, streptozotocin treated for 5 days, induced diabetes in normal BALB/c recipients. Treatment of transplants with anti-theta and complement resulted in a significant decrease in the degree of diabetes. Athymic nude mouse recipients of BALB/c background also developed diabetes after transpant of spleen cells from both syngenic and allogenic (C-7/Bl/6) donors. It is concluded that passive transfer of chemically induced diabetes in mice is practicable, in both syngeneic and allogeneic combinations, and that thymus derived lymphocytes are significant in this process.

摘要

本研究显示链脲佐菌素诱导的小鼠糖尿病可被动转移。将经链脲佐菌素处理5天的BALB/c小鼠的脾细胞移植到正常BALB/c受体小鼠中可诱导糖尿病。用抗θ抗体和补体处理移植细胞，可使糖尿病程度显著降低。具有BALB/c背景的无胸腺裸鼠受体在移植同基因和异基因（C-7/Bl/6）供体的脾细胞后也会发生糖尿病。得出的结论是，在同基因和异基因组合中，化学诱导的小鼠糖尿病的被动转移都是可行的，并且胸腺来源的淋巴细胞在这一过程中起重要作用。

相似文献

1
Passive transfer of streptozotocin induced diabetes mellitus with spleen cells. Studies of synogeneic and allogeneic transfer to normal and athymic nude mice.用脾细胞进行链脲佐菌素诱导的糖尿病的被动转移。对正常和无胸腺裸鼠进行同基因和异基因转移的研究。
Acta Pathol Microbiol Scand C. 1977 Dec;85C(6):469-72. doi: 10.1111/j.1699-0463.1977.tb03670.x.
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引用本文的文献

1
Transfer of experimental autoimmune insulitis by spleen cells in mice.
Diabetologia. 1980;19(6):516-20. doi: 10.1007/BF00253178.
2
Strain dependency of the transfer of experimental immune insulitis in mice.小鼠实验性免疫性胰岛炎转移的品系依赖性
Clin Exp Immunol. 1981 Feb;43(2):430-3.
3
Insulin-dependent diabetes mellitus induced by subdiabetogenic doses of streptozotocin: obligatory role of cell-mediated autoimmune processes.亚致糖尿病剂量链脲佐菌素诱导的胰岛素依赖型糖尿病：细胞介导的自身免疫过程的必要作用
Proc Natl Acad Sci U S A. 1980 Oct;77(10):6129-33. doi: 10.1073/pnas.77.10.6129.
4
Irradiation protects against pancreatic islet degeneration and hyperglycaemia following streptozotocin treatment of mice.对小鼠进行链脲佐菌素治疗后，照射可预防胰岛退化和高血糖症。
Diabetologia. 1983 May;24(5):382-6. doi: 10.1007/BF00251829.
5
Disordered cellular immunity in type I diabetes of man and the BB rat.人类和BB大鼠I型糖尿病中的细胞免疫紊乱。
Surv Immunol Res. 1982;1(4):339-51. doi: 10.1007/BF02918546.
6
Low-dose streptozotocin-induced autoimmune diabetes is under the genetic control of the major histocompatibility complex in mice.
Diabetologia. 1982 Jul;23(1):69-71. doi: 10.1007/BF00257735.
7
The low dose streptozotocin murine model of type 1 (insulin-dependent) diabetes mellitus: studies in vivo and in vitro of the modulating effect of sex hormones.1型（胰岛素依赖型）糖尿病的低剂量链脲佐菌素小鼠模型：性激素调节作用的体内和体外研究
Diabetologia. 1982 Mar;22(3):194-8. doi: 10.1007/BF00283752.