Department of Genetics, Sanjay Gandhi Post Graduate Institute of Medical Sciences, Lucknow, India.
DNA Cell Biol. 2011 May;30(5):297-303. doi: 10.1089/dna.2010.1115. Epub 2011 Feb 7.
quinone oxidoreductase 1 (NQO1) and dihydronicotinamide riboside: quinone oxidoreductase 2 (NQO2) are cytosolic enzymes that catalyze reductive activation of carcinogens from cigarette smoke, such as nitrosamines and heterocyclic amines. These enzymes also protect cells against oxidative damage from reactive oxygen species. The present study investigated the associations of genetic variants of NQO1 609C>T and NQO2 -3423G>A polymorphisms with susceptibility to gastric cancer (GC) as well as their interactions with known risk factors in Kashmir valley. A case control study was performed in 303 subjects (108 GC and 195 healthy controls). All subjects were genotyped using polymerase chain reaction-restriction fragment length polymorphism method. Data were statistically analyzed by chi-square test and logistic regression model. The NQO1 609C>T TT genotype and T allele were significantly associated with increased risk for GC, whereas NQO2 -3423G>A polymorphism did not show any association with GC. Also, NQO1 609C>T TT genotype showed significant association with gastric adenocarcinoma. The interaction of NQO1/NQO2 genotypes with high consumption of salted tea, a known risk factor, did not further modulate the risk of GC. In conclusion, NQO1 609C>T polymorphism shows association with GC risk in Kashmir valley.
醌氧化还原酶 1（NQO1）和二氢烟酰胺核糖：醌氧化还原酶 2（NQO2）是细胞溶质酶，可催化香烟烟雾中的致癌物（如亚硝胺和杂环胺）的还原激活。这些酶还可以保护细胞免受活性氧引起的氧化损伤。本研究探讨了 NQO1 609C>T 和 NQO2-3423G>A 多态性的遗传变异与克什米尔山谷胃癌（GC）易感性的关联，以及它们与已知危险因素的相互作用。在 303 名受试者（108 名 GC 和 195 名健康对照）中进行了病例对照研究。所有受试者均采用聚合酶链反应-限制性片段长度多态性方法进行基因分型。数据采用卡方检验和逻辑回归模型进行统计学分析。NQO1 609C>T TT 基因型和 T 等位基因与 GC 风险增加显著相关，而 NQO2-3423G>A 多态性与 GC 无关联。此外，NQO1 609C>T TT 基因型与胃腺癌显著相关。NQO1/NQO2 基因型与高盐茶（已知危险因素）的相互作用不会进一步调节 GC 的风险。总之，NQO1 609C>T 多态性与克什米尔山谷的 GC 风险相关。
