Ducrotte P, Parent B, Masliah C, Joubert M, Colin R, Denis P
Groupe de Biochimie et de Physiopathologie Digestive et Nutritionnelle, Hôpital Charles Nicolle, Rouen, France.
Aliment Pharmacol Ther. 1990 Feb;4(1):73-81. doi: 10.1111/j.1365-2036.1990.tb00451.x.
Motor changes could be involved in the pathogenesis of diarrhoea that complicates the treatment of ulcer disease by prostaglandins. Our aim was to assess the effect of enprostil, a synthetic analogue of PGE2, on duodeno-jejunal motility. During this randomized double-blind crossover study, two manometric recordings, each lasting 20 h (12.00-08.00 hours), were carried out during dosing with 35 micrograms enprostil b.d. or placebo (eight volunteers: part 1), or during dosing with 35 or 70 micrograms enprostil b.d. (nine volunteers: part 2). Subjects were only allowed a standard dinner at 18.00 hours. During fasting, in part 1, the number of phase 3 activity patterns (PIIIs) was higher with enprostil than with placebo (P less than 0.01), without any difference in their characteristics; the overall duration of phase 1 activity was longer with enprostil than with placebo (P less than 0.01). In part 2, during fasting the number and characteristics of the PIIIs were not different, but there was a dose-related increase in PI, and decrease in PII activity. Fed motor patterns did not differ between the two doses of enprostil.
运动变化可能参与了前列腺素治疗溃疡病时并发腹泻的发病机制。我们的目的是评估前列腺素E2的合成类似物恩前列素对十二指肠-空肠运动的影响。在这项随机双盲交叉研究中，在每日两次服用35微克恩前列素或安慰剂期间（8名志愿者：第1部分），或在每日两次服用35或70微克恩前列素期间（9名志愿者：第2部分），进行了两次测压记录，每次持续20小时（12:00 - 08:00）。受试者仅允许在18:00吃一顿标准晚餐。在禁食期间，第1部分中，恩前列素组的3期活动模式（PIIIs）数量高于安慰剂组（P < 0.01），但其特征无差异；恩前列素组的1期活动总持续时间长于安慰剂组（P < 0.01）。在第2部分中，禁食期间PIIIs的数量和特征无差异，但PI有剂量相关增加，PII活动减少。两种剂量的恩前列素之间的进食运动模式无差异。
