Cohen M M, McCready D R, Clark L, Sevelius H
Gastroenterology. 1985 Jan;88(1 Pt 2):382-6. doi: 10.1016/s0016-5085(85)80193-1.
Prostaglandins protect against aspirin-induced damage to the gastrointestinal tract. This study tested the ability of enprostil, a synthetic analog of prostaglandin E2, given concurrently to prevent gastroduodenal injury. Twenty-four healthy subjects were randomly assigned to one of three groups. All received aspirin 650 mg q.i.d. for 5 days. One group received placebo and the other groups were given either 7 or 70 micrograms of enprostil b.i.d. for 5 days. Upper endoscopy was performed at entry and 2 h after the final dose of aspirin. Enprostil 70 micrograms b.i.d. afforded significant protection of both the antral and duodenal mucosa. The 7-micrograms dose protected only the antral mucosa. Side effects were not observed with the lower dose of enprostil. Serum salicylate levels did not differ significantly between the groups.
前列腺素可预防阿司匹林引起的胃肠道损伤。本研究测试了同时给予前列腺素E2的合成类似物恩前列素预防胃十二指肠损伤的能力。24名健康受试者被随机分为三组。所有人均接受650毫克阿司匹林，每日四次，共5天。一组接受安慰剂，其他两组分别给予7或70微克恩前列素，每日两次，共5天。在入组时以及最后一剂阿司匹林服用后2小时进行上消化道内镜检查。每日两次给予70微克恩前列素可显著保护胃窦和十二指肠黏膜。7微克剂量仅保护胃窦黏膜。较低剂量的恩前列素未观察到副作用。各组之间血清水杨酸水平无显著差异。
