Department of Translational Medicine, Brigham and Women's Hospital and Harvard Medical School, 1 Blackfan Circle, Boston, MA 02115, USA.
FEBS Lett. 2011 Mar 9;585(5):723-9. doi: 10.1016/j.febslet.2011.01.041. Epub 2011 Feb 2.
Microbial pathogens cause widespread morbidity and mortality. Central to the pathogens' virulence is manipulation of the host cell's cytoskeleton, which facilitates microbial invasion, multiplication, and avoidance of the innate immune response. IQGAP1 is a ubiquitously expressed scaffold protein that integrates diverse signaling cascades. Research has shown that IQGAP1 binds to and modulates the activity of multiple proteins that participate in bacterial invasion. Here, we review data that support a role for IQGAP1 in infectious disease via its ability to regulate the actin cytoskeleton. In addition, we explore other mechanisms by which IQGAP1 may be exploited by microbial pathogens.
微生物病原体导致广泛的发病率和死亡率。病原体的毒力的核心是操纵宿主细胞的细胞骨架，这有助于微生物的入侵、繁殖和逃避先天免疫反应。IQGAP1 是一种广泛表达的支架蛋白，它整合了多种信号级联反应。研究表明，IQGAP1 结合并调节参与细菌入侵的多种蛋白质的活性。在这里，我们通过其调节肌动蛋白细胞骨架的能力来回顾支持 IQGAP1 在传染病中发挥作用的数据。此外，我们还探讨了微生物病原体可能利用 IQGAP1 的其他机制。
