Department of Psychology, Palm Beach Atlantic University, PO Box 24708, West Palm Beach, Florida 33416-4708, USA.
Physiol Behav. 2011 May 3;103(2):203-9. doi: 10.1016/j.physbeh.2011.01.021. Epub 2011 Feb 2.
Foxy or Methoxy Foxy (5-methoxy-N,N-di(iso)propyltryptamine hydrochloride; 5-MeO-DIPT) is rapidly gaining popularity among recreational users as a hallucinogenic "designer drug." Unfortunately, much remain unknown about the consequences of its use on neuropsychological development or behavior. During one of two adolescent periods, the rats were given repeated injections of 5 mg/kg or 20 mg/kg of 5-MeO-DIPT or a corresponding volume of isotonic saline. After the animals reached adulthood, they were trained and tested on a number of tasks designed to assess the impact of 5-MeO-DIPT, if any, on spatial memory, presumably involving declarative memory systems as well as a nonspatial task that is considered sensitive to disruptions in nondeclarative memory. Both the 5-MeO-DIPT- and saline-treated rats were able to master spatial navigation tests where the task included a single goal location and all groups performed comparably on these phases of training and testing. Regardless of exposure level during adolescence, the performance of the drug-treated rats was markedly inferior to that of the control animals on a task where the goal was moved to a new location and on a response learning task, suggesting a lack of flexibility in adapting their responses to changing task demands. Detected reductions in serotonin activity in the forebrain similar to the effects of extensively investigated compounds such as methylenedioxymethamphetamine (MDMA), suggest that 5-MeO-DIPT may produce its adverse effects by compromising serotonergic systems in the brain.
福西或甲氧基福西（5-甲氧基-N，N-二（异）丙基色胺盐酸盐；5-MeO-DIPT）作为一种致幻“设计药物”，在娱乐性使用者中迅速流行。不幸的是，关于其对神经心理发育或行为的影响，人们知之甚少。在两个青少年时期之一期间，大鼠接受重复注射 5mg/kg 或 20mg/kg 的 5-MeO-DIPT 或相应体积的等渗盐水。动物成年后，它们接受了一系列任务的训练和测试，这些任务旨在评估 5-MeO-DIPT 的影响（如果有）对空间记忆的影响，这可能涉及陈述性记忆系统以及被认为对非陈述性记忆中断敏感的非空间任务。接受 5-MeO-DIPT 和盐水治疗的大鼠都能够掌握空间导航测试，其中任务包括一个单一的目标位置，所有组在这些训练和测试阶段的表现都相当。无论青少年时期的暴露水平如何，与对照动物相比，药物治疗大鼠在目标移至新位置的任务和反应学习任务上的表现明显较差，这表明它们在适应不断变化的任务需求方面缺乏灵活性。在前脑检测到的血清素活性降低与广泛研究的化合物（如 3,4-亚甲基二氧基甲基苯丙胺（MDMA））的作用相似，表明 5-MeO-DIPT 可能通过损害大脑中的血清素系统产生其不良影响。
