Skelton Matthew R, Schaefer Tori L, Herring Nicole R, Grace Curtis E, Vorhees Charles V, Williams Michael T
Division of Neurology, Cincinnati Children's Research Foundation and University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA.
Psychopharmacology (Berl). 2009 Jun;204(2):287-97. doi: 10.1007/s00213-009-1459-x. Epub 2009 Feb 6.
We have previously shown that (+/-)-3,4-methylenedioxymethamphetamine (MDMA) treatment from postnatal days (P)11 to P20 leads to learning and memory deficits when the animals are tested as adults. Recently, the club drug 5-methoxy-N,N-diisopropyltryptamine (5-MeO-DIPT) has gained popularity.
Due to the similarities between MDMA and 5-MeO-DIPT and the substitution of 5-MeO-DIPT for MDMA, the purpose of this study was to compare the developmental effects of these drugs.
Within a litter, animals were treated from P11 to P20 with either MDMA, 5-MeO-DIPT, or saline.
MDMA-treated animals showed increased anxiety in a measure of defensive marble burying, as well as deficits in spatial and path integration learning. 5-MeO-DIPT-treated animals showed spatial learning deficits; however, there were no deficits observed in spatial memory or path integration learning. 5-MeO-DIPT-treated animals also showed hyperactivity in response to a challenge dose of methamphetamine.
The results show that treatment with either 5-MeO-DIPT or MDMA during development results in cognitive deficits and other behavioral changes but the pattern of effects is distinct for each drug.
我们之前已经表明，从出生后第11天（P11）到第20天（P20）给予（±）-3,4-亚甲基二氧甲基苯丙胺（摇头丸）治疗，当动物成年后接受测试时会导致学习和记忆缺陷。最近，俱乐部毒品5-甲氧基-N,N-二异丙基色胺（5-MeO-DIPT）越来越受欢迎。
由于摇头丸和5-MeO-DIPT之间的相似性以及5-MeO-DIPT对摇头丸的替代，本研究的目的是比较这些药物的发育影响。
在一窝动物中，从P11到P20用摇头丸、5-MeO-DIPT或生理盐水对动物进行治疗。
接受摇头丸治疗的动物在防御性埋球实验中表现出焦虑增加，以及空间和路径整合学习方面的缺陷。接受5-MeO-DIPT治疗的动物表现出空间学习缺陷；然而，在空间记忆或路径整合学习中未观察到缺陷。接受5-MeO-DIPT治疗的动物在给予甲基苯丙胺激发剂量后也表现出多动。
结果表明，在发育过程中用5-MeO-DIPT或摇头丸治疗会导致认知缺陷和其他行为变化，但每种药物的影响模式是不同的。
