Department of Neurology, Washington University School of Medicine, St. Louis, Missouri, USA.
Curr Top Dev Biol. 2011;94:283-308. doi: 10.1016/B978-0-12-380916-2.00009-7.
The neurofibromatosis type 1 (NF1) tumor predisposition syndrome provides an illustrative example of brain tumor formation and growth in which a permissive microenvironment (stroma) is required for the expansion and maintenance of the neoplastic cells. In this chapter, we review the experimental evidence that supports the emerging concept that brain tumors are dynamic ecosystems where interactions between non-neoplastic and neoplastic cell types dictate where and when gliomas (astrocytomas) form and grow. The notion that brain tumors require a confluence of supportive stromal cell types and signals, susceptible preneoplastic/neoplastic cells, and genomic influences allows researchers and clinicians to develop strategies that effectively disrupt these critical relationships in a targeted and developmentally appropriate fashion.
神经纤维瘤病 1 型（NF1）肿瘤易感性综合征为脑瘤的形成和生长提供了一个说明性的例子，其中允许的微环境（基质）对于肿瘤细胞的扩增和维持是必需的。在这一章中，我们回顾了支持新兴概念的实验证据，即脑瘤是一个动态的生态系统，其中非肿瘤细胞和肿瘤细胞类型之间的相互作用决定了神经胶质瘤（星形细胞瘤）何时何地形成和生长。脑瘤需要汇聚支持性基质细胞类型和信号、易感性的肿瘤前/肿瘤细胞以及基因组影响的观点，使研究人员和临床医生能够以靶向和适当的发育方式有效地破坏这些关键关系。
