Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA.
Oncogene. 2011 Mar 10;30(10):1135-46. doi: 10.1038/onc.2010.519. Epub 2010 Nov 15.
Traditionally, cancer studies have primarily focused on mutations that activate growth or survival pathways in susceptible pre-neoplastic/neoplastic cells. However, recent research has revealed a critical role for non-neoplastic cells within the tumor microenvironment in the process of cancer formation and progression. In addition, the existence of regional and developmental variations in susceptible cell types and supportive microenvironments support a model of tumorigenesis in which the dynamic symbiotic relationship between neoplastic and non-neoplastic cell types dictate where and when cancers form and grow. In this review, we highlight advances in neurofibromatosis type 1 (NF1) genetically engineered mouse brain tumor (glioma) modeling to reveal how cellular and molecular heterogeneity in both the pre-neoplastic/neoplastic and non-neoplastic cellular compartments contribute to gliomagenesis and glioma growth.
传统上，癌症研究主要集中在激活易感前瘤/瘤细胞生长或存活途径的突变上。然而，最近的研究揭示了肿瘤微环境中非瘤细胞在癌症形成和进展过程中的关键作用。此外，易感细胞类型和支持性微环境在区域和发育上的变化存在，支持了一种肿瘤发生的模型，即肿瘤和非肿瘤细胞类型之间的动态共生关系决定了癌症在哪里以及何时形成和生长。在这篇综述中，我们强调了神经纤维瘤病 1 型（NF1）基因工程小鼠脑肿瘤（神经胶质瘤）模型的进展，以揭示前瘤/瘤和非瘤细胞区室中的细胞和分子异质性如何促进神经胶质瘤发生和神经胶质瘤生长。
