一种多功能的糖基转移酶脱颖而出。
A versatile sugar transferase makes the cut.
机构信息
Laboratory of Cellular and Molecular Biology, NIDDK, National Institutes of Health, Bethesda, MD 20892-0851, USA.
出版信息
Cell. 2011 Feb 4;144(3):321-3. doi: 10.1016/j.cell.2011.01.025.
Abstract
The nutrient sensor O-GlcNAc transferase modifies proteins with the O-GlcNAc moiety. In this issue, Capotosti et al. (2011) reveal that O-GlcNAc transferase not only glycosylates the cell-cycle regulator host cell factor 1 but activates it through proteolytic cleavage, providing a surprising link between metabolism and epigenetic regulation of the cell cycle.
摘要
营养传感器 O-连接的 N-乙酰葡萄糖胺转移酶（O-GlcNAc transferase）用 O-GlcNAc 修饰蛋白质。在本期中，Capotosti 等人（2011）揭示了 O-GlcNAc 转移酶不仅糖基化细胞周期调节因子宿主细胞因子 1（host cell factor 1），而且通过蛋白水解切割使其激活，为代谢与细胞周期的表观遗传调控之间提供了一个令人惊讶的联系。
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