Kjelgaard-Hansen Mads, Jacobsen Stine
Department of Small Animal Clinical Sciences, Faculty of LIFE Sciences, University of Copenhagen, Frederiksberg C, Denmark.
Clin Lab Med. 2011 Mar;31(1):51-70. doi: 10.1016/j.cll.2010.10.002. Epub 2010 Dec 3.
The use of major acute-phase proteins (APPs) for assessment of health and disease in companion animals has increased within the last decade because of increased knowledge in the field and increased access to appropriate assay systems for detection of relevant APPs, which are highly species specific. Despite evidence being restricted almost solely to proven excellent overlap performance of these markers in detecting inflammatory activity, clinically relevant studies at higher evidence levels do exist. The available body of literature shows a clear, but seemingly untapped, potential for more extended routine clinical use of major APP testing in companion animal medicine.
在过去十年中，由于该领域知识的增加以及用于检测相关主要急性期蛋白（APPs）的合适检测系统的可及性提高，APPs在伴侣动物健康和疾病评估中的应用有所增加，这些APPs具有高度的物种特异性。尽管证据几乎完全局限于这些标志物在检测炎症活动方面已被证实具有出色的重叠性能，但确实存在更高证据水平的临床相关研究。现有文献表明，在伴侣动物医学中更广泛地常规临床应用主要APP检测具有明显但似乎尚未开发的潜力。
