University of Tuebingen, Department of Otolaryngology, Elfriede-Aulhorn-Straße, Germany.
J Cyst Fibros. 2011 May;10(3):181-6. doi: 10.1016/j.jcf.2011.01.003. Epub 2011 Feb 4.
Chronic sinusitis is almost invariably a feature of cystic fibrosis. However, data on the endoscopically confirmed prevalence of chronic polypoid sinusitis (CPS) and its histological features are limited.
Single centre prospective observational study. Unselected pediatric CF patients (n=81; ≤ 18 years) were endoscopically assessed for the prevalence of CPS. Sixteen of these underwent sinus surgery. The surgically obtained sinus specimens were compared to sinus specimen of non-CF-patients undergoing sinus surgery (n=61), using conventional histology and immunohistochemistry.
The prevalence of endoscopically confirmed CPS increased with age from 19% in infants younger than six years reaching 45% in adolescents. In CF patients, histology typically showed dilated glandular ducts and a predominance of mucous glands. The number of plasma cells and mast cells but not of eosinophils was significantly elevated compared to non-CF patients.
Prevalence of CPS in pediatric CF patients increases with age. Our findings indicate that chronic bacterial infection rather than allergic mechanisms may forward this pathology.
慢性鼻窦炎几乎是囊性纤维化的特征。然而，关于内镜确诊的慢性息肉样鼻窦炎（CPS）及其组织学特征的数据有限。
单中心前瞻性观察研究。对 81 例（≤18 岁）未选择的儿科 CF 患者进行内镜评估 CPS 的患病率。其中 16 例行鼻窦手术。使用常规组织学和免疫组织化学方法，将这些鼻窦手术标本与非 CF 患者鼻窦手术（n=61）的鼻窦标本进行比较。
内镜确诊的 CPS 的患病率随年龄增长而增加，6 岁以下婴儿为 19%，青少年为 45%。在 CF 患者中，组织学通常显示扩张的腺管和粘液腺占主导地位。与非 CF 患者相比，浆细胞和肥大细胞的数量显著增加，但嗜酸性粒细胞的数量没有增加。
儿科 CF 患者 CPS 的患病率随年龄增长而增加。我们的发现表明，慢性细菌感染而不是过敏机制可能导致这种病理。
