Department of Molecular and Cell Biology, Division of Cell and Developmental Biology, University of California, Berkeley, CA 94720-3200, United States.
Curr Opin Cell Biol. 2011 Jun;23(3):293-301. doi: 10.1016/j.ceb.2011.01.002. Epub 2011 Feb 4.
Nuclear pore complexes (NPCs) are highly selective transport gates that enable the bi-directional traffic of macromolecules across the nuclear envelope (NE). NPCs are located at the fusion pores between the inner and outer membranes of the NE and are built from a common set of ∼30 different proteins, nucleoporins. Remarkably, recent proteomic, bioinformatic, and structural studies have provided firm evidence that key structural nucleoporins share common ancestry with elements of coated vesicles, indicating an evolutionary link between these structures. This has provided novel insight into the origin of NPCs and may help us to better functionally characterize these fundamental components of eukaryotic cells.
核孔复合体（NPC）是高度选择性的运输门，允许大分子在内核膜（NE）的两侧进行双向运输。NPC 位于 NE 内外膜之间的融合孔处，由大约 30 种不同的蛋白质组成，即核孔蛋白。值得注意的是，最近的蛋白质组学、生物信息学和结构研究提供了确凿的证据，表明关键的结构核孔蛋白与披网格蛋白小泡的元件具有共同的祖先，这表明这些结构之间存在进化联系。这为 NPC 的起源提供了新的见解，并可能有助于我们更好地对真核细胞的这些基本成分进行功能表征。
