Laboratório da Disciplina de Patologia de Moléstias Transmissíveis, Departamento de Patologia, Faculdade de Medicina da Universidade de São Paulo, Brazil.
Microb Pathog. 2011 May;50(5):263-7. doi: 10.1016/j.micpath.2010.12.008. Epub 2011 Feb 3.
We demonstrated and quantified by immunohistochemistry the population of cells expressing IL17 and Foxp3 in cutaneous and mucosal paracoccidioidomycosis lesions, associating these populations of cells with different presentations of granulomatous response. For this purpose, 61 skin biopsies and 55 oral mucosal biopsies were evaluated. Cells expressing IL17 were distributed in the inflammatory infiltrate in both groups of lesions and were found in the vessels' wall too. Foxp3+ expression was limited to the nuclei of lymphocytes in the inflammatory infiltrate. The distribution of IL17 was similar among the groups; however, Foxp3+ cells were increased in mucosal lesions that displayed compact granulomas. The results suggest that IL17 seems to play a role in paracoccidioidomycosis cutaneous and mucosal lesions, probably as secondary cells in the clearance of the fungal antigens. The presence of Foxp3+ cells both in skin and mucosa corroborates some previous researches that suggest the role of this group of cells in the modulation of local immune response.
我们通过免疫组织化学方法证明并量化了皮肤和粘膜组织胞浆菌病病变中表达 IL17 和 Foxp3 的细胞群体，并将这些细胞群体与不同的肉芽肿反应表现相关联。为此，评估了 61 份皮肤活检和 55 份口腔粘膜活检。表达 IL17 的细胞分布在两组病变的炎症浸润中，也存在于血管壁中。Foxp3+ 表达仅限于炎症浸润中的淋巴细胞核。IL17 的分布在各组之间相似；然而，在显示致密肉芽肿的粘膜病变中，Foxp3+细胞增加。结果表明，IL17 似乎在皮肤和粘膜组织胞浆菌病病变中发挥作用，可能作为清除真菌抗原的次要细胞。Foxp3+细胞在皮肤和粘膜中的存在证实了一些先前的研究，这些研究表明该细胞群在调节局部免疫反应中的作用。
