Departamento de Patologia, Faculdade de Medicina, Universidade de São Paulo, Brazil.
Microbes Infect. 2011 Nov;13(12-13):1012-7. doi: 10.1016/j.micinf.2011.06.006. Epub 2011 Jul 1.
Langerhans cells are identified by the expression of langerin. We detected this molecule in cutaneous and mucosal lesions in paracoccidioidomycosis, an important infection in Latin America. Langerin+ cells were scarcely distributed, with short dendrites in epidermis and epithelium and were frequent in the dermis and corium, in the inflammatory infiltrate and granulomas. Mucosal lesions presented a higher expression of langerin in lesions with loose granulomas. For the first time we presented the expression of langerin in paracoccidioidomycosis. Positive cells in dermis and corium could represent migrating Langerhans cells or a new subset of langerin+ cells with a role in paracoccidioidomycosis.
朗格汉斯细胞通过朗格汉斯蛋白的表达来鉴定。我们在皮肤和黏膜的副球孢子菌病病变中检测到这种分子，副球孢子菌病是拉丁美洲的一种重要感染。朗格汉斯蛋白+细胞分布稀疏，在表皮和上皮中树突短，在真皮和真皮中常见，在炎症浸润和肉芽肿中常见。黏膜病变中，松散型肉芽肿的朗格汉斯蛋白表达更高。我们首次在副球孢子菌病中展示了朗格汉斯蛋白的表达。真皮和真皮中的阳性细胞可能代表迁移的朗格汉斯细胞，或在副球孢子菌病中具有作用的朗格汉斯蛋白+细胞的新亚群。
