中枢神经系统中对拉替拉韦耐药的HIV-1的出现。
Emergence of raltegravir-resistant HIV-1 in the central nervous system.
作者信息
Watanabe K, Honda M, Watanabe T, Tsukada K, Teruya K, Kikuchi Y, Oka S, Gatanaga H
机构信息
AIDS Clinical Center, National Center for Global Health and Medicine, Tokyo, Japan.
出版信息
Int J STD AIDS. 2010 Dec;21(12):840-1. doi: 10.1258/ijsa.2009.009283.
Integrase inhibitor-resistant HIV-1 was detected in the cerebrospinal fluid, but not in the plasma of a 42-year-old man with HIV encephalopathy treated with a raltegravir (RAL)-containing regimen. Raltegravir resistance may develop in the central nervous system when the virus is already multi-drug resistant because of different penetration into cerebrospinal fluid of individual antiretroviral agents.
在一名接受含raltegravir（RAL）方案治疗的42岁HIV脑病男性患者的脑脊液中检测到整合酶抑制剂耐药的HIV-1，但血浆中未检测到。当病毒由于个体抗逆转录病毒药物进入脑脊液的渗透率不同而已经对多种药物耐药时，raltegravir耐药可能在中枢神经系统中出现。
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