Kawada Tomoyuki, Inagaki Hirofumi, Wakayama Yoko, Katsumata Masao, Li Qing, Li Ying-Ji, Otsuka Toshiaki
Department of Hygiene and Public Health, Nippon Medical School, Japan.
Work. 2011;38(2):123-7. doi: 10.3233/WOR-2011-1114.
It has been suggested that the presence of a depressive state is a predictor of increase of the body weight. However, to precisely understand the nature of this relationship, the data should be controlled for other factors that can also be associated with weight gain.
To test the hypothesis that the presence of a depressive state is associated with future weight gain, a 4-year prospective occupation-based cohort study was conducted in male adult workers (N=1730) at a railway company. Following the initial screening, follow-up information was obtained via a legally required annual health examination. The presence of a depressive state was identified using the Zung Self-Rating Depression Scale (SDS). The weight of each participant was measured to the nearest kilogram. Multiple logistic regression analysis was used to test the association between the depressive state and a weight gain of 4 kg or more over the 4-year study period after controlling for potentially confounding variables such as the age, smoking status, alcohol intake status, and physical activity.
A weight gain of 4 kg or more over the 4-year study period was significantly associated with the depressive state, even after controlling for confounding variables (p< 0.05). Short-term longitudinal analysis also revealed an association between the depressive state and subsequent increase of the body weight.
Since the depressive state was demonstrated to be an important risk factor for increase of the body weight, further research on depression should be conducted with a view to providing effective health education.
有人提出抑郁状态的存在是体重增加的一个预测指标。然而，为了精确理解这种关系的本质，数据应针对其他也可能与体重增加相关的因素进行控制。
为了检验抑郁状态的存在与未来体重增加相关这一假设，在一家铁路公司对成年男性工人（N = 1730）进行了一项为期4年的基于职业的前瞻性队列研究。在初始筛查之后，通过法定的年度健康检查获取随访信息。使用zung自评抑郁量表（SDS）确定抑郁状态的存在。将每位参与者的体重测量至最接近的千克数。在控制了年龄、吸烟状况、饮酒状况和身体活动等潜在混杂变量之后，使用多元逻辑回归分析来检验抑郁状态与在4年研究期间体重增加4千克或更多之间的关联。
即使在控制了混杂变量之后，在4年研究期间体重增加4千克或更多仍与抑郁状态显著相关（p < 0.05）。短期纵向分析也揭示了抑郁状态与随后体重增加之间的关联。
由于抑郁状态被证明是体重增加的一个重要风险因素，应针对抑郁症开展进一步研究，以便提供有效的健康教育。
