Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, 65 Tsurumai-cho, Showa-ku, Nagoya, Aichi 466-8550, Japan.
J Clin Biochem Nutr. 2011 Jan;48(1):46-9. doi: 10.3164/jcbn.11-001FR. Epub 2010 Dec 28.
Persistent oxidative stress has been associated with carcinogenesis. Iron overload is considered one such condition that causes oxidative stress. Epidemiological studies support a close link between iron overload and carcinogenesis. Reportedly, regular semiannual phlebotomies reduced cancer risk in an otherwise normal population. More specifically, genetic hemochromatosis, chronic viral hepatitis, ovarian endometriosis and asbestosis induce iron overload, which can lead to hepatocellular carcinoma, ovarian carcinoma or mesothelioma in humans. Through a combination of animal experiments and microarray analyses, homozygous deletion of CDKN2A/2B has been recognized as one of the major target genes involved in iron overload-induced carcinogenesis. CDKN2A/2B are the second most frequently inactivated tumor suppressing genes in human cancers. Currently, when infection is becoming sufficiently controlled worldwide, iron regulation may be the next target for human longevity.
持续的氧化应激与致癌作用有关。铁过载被认为是导致氧化应激的一种情况。流行病学研究支持铁过载与致癌作用之间的密切联系。据报道，定期每半年放血一次可降低正常人群的癌症风险。更具体地说，遗传性血色素沉着症、慢性病毒性肝炎、卵巢子宫内膜异位症和石棉沉着病会导致铁过载，从而导致人类发生肝细胞癌、卵巢癌或间皮瘤。通过动物实验和微阵列分析的结合，已经认识到 CDKN2A/2B 的纯合缺失是铁过载诱导的致癌作用涉及的主要靶基因之一。CDKN2A/2B 是人类癌症中第二大最常失活的肿瘤抑制基因。目前，当全世界的感染得到充分控制时，铁的调节可能成为人类长寿的下一个目标。
