CAS Key Laboratory of Brain Function and Disease, and School of Life Sciences, University of Science and Technology of China, Hefei, China.
PLoS One. 2011 Jan 26;6(1):e16560. doi: 10.1371/journal.pone.0016560.
The default mode network (DMN) is a set of brain regions that exhibit synchronized low frequency oscillations at resting-state, and is believed to be relevant to attention and self-monitoring. As the anterior cingulate cortex and hippocampus are impaired in drug addiction and meanwhile are parts of the DMN, the present study examined addiction-related alteration of functional connectivity of the DMN.
Resting-state functional magnetic resonance imaging data of chronic heroin users (14 males, age: 30.1±5.3 years, range from 22 to 39 years) and non-addicted controls (13 males, age: 29.8±7.2 years, range from 20 to 39 years) were investigated with independent component analysis to address their functional connectivity of the DMN.
Compared with controls, heroin users showed increased functional connectivity in right hippocampus and decreased functional connectivity in right dorsal anterior cingulate cortex and left caudate in the DMN.
These findings suggest drug addicts' abnormal functional organization of the DMN, and are discussed as addiction-related abnormally increased memory processing but diminished cognitive control related to attention and self-monitoring, which may underlie the hypersensitivity toward drug related cues but weakened strength of cognitive control in the state of addiction.
默认模式网络（DMN）是一组在静息状态下表现出同步低频振荡的脑区，被认为与注意力和自我监控有关。由于药物成瘾会损害前扣带皮层和海马体，而这两个区域同时也是 DMN 的一部分，因此本研究探讨了 DMN 的功能连接与成瘾之间的关系。
使用独立成分分析对慢性海洛因使用者（14 名男性，年龄：30.1±5.3 岁，年龄范围为 22 至 39 岁）和非成瘾对照者（13 名男性，年龄：29.8±7.2 岁，年龄范围为 20 至 39 岁）的静息态功能磁共振成像数据进行了研究，以探讨 DMN 的功能连接。
与对照组相比，海洛因使用者的 DMN 中右侧海马体的功能连接增强，而右侧前扣带皮层和左侧尾状核的功能连接减弱。
这些发现表明药物成瘾者 DMN 的功能组织异常，这可能与成瘾状态下对药物相关线索的敏感性增加但认知控制减弱有关，而认知控制减弱与注意力和自我监控有关。
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