Faculty of Medicine, University of Iceland, Reykjavík, Iceland; Department of Clinical Sciences, Lund University, Lund, Sweden.
Pediatr Blood Cancer. 2011 Apr;56(4):631-7. doi: 10.1002/pbc.22876. Epub 2010 Dec 15.
Chemotherapy is used in the treatment of children and adolescents with malignant diseases. Some of the chemotherapeutic agents are highly toxic and may cause a number of side effects. The primary objective of this study was to evaluate the long-term effects on hearing in cancer survivors who had received platinum-based chemotherapy in childhood or adolescence.
Medical records of 297 patients, who had received treatment for cancer at the Children's Hospital, Landspitali University Hospital in Iceland between 1981 and 2006, were retrospectively reviewed. Fifteen subjects fulfilled the eligibility criteria for the study and underwent an extended audiometric evaluation.
The results showed that three of the subjects had a high frequency hearing loss. In one subject, we observed a hearing recovery just after the completion of chemotherapy, but the hearing deteriorated again some years later. Nine of the 15 subjects (60%) had tinnitus after the cancer treatment. An evaluation of subjective hearing disability and handicap (The Hearing Measurements Scale) revealed that some subjects had great difficulties with hearing in certain situations. The Hearing Measurement Scale showed that the pure-tone audiogram findings were only partly associated with the apparent hearing difficulties.
Regular follow-up hearing examinations, which include both pure-tone audiogram investigations and subjective hearing disability assessments, should be performed during and after chemotherapy to identify subjects who require particular attention. This will ensure that hearing impaired individuals are provided with the most suitable listening devices, to promote good speech and social development.
化疗用于治疗儿童和青少年的恶性疾病。一些化疗药物具有高度毒性，可能会引起许多副作用。本研究的主要目的是评估曾在儿童或青少年时期接受过基于铂类的化疗的癌症幸存者的长期听力影响。
回顾性审查了 1981 年至 2006 年期间在冰岛 Landspitali 大学儿童医院接受癌症治疗的 297 名患者的医疗记录。有 15 名患者符合研究标准，并接受了扩展的听力评估。
结果显示，有 3 名患者出现高频听力损失。在一名患者中，我们观察到化疗完成后听力有所恢复，但几年后听力再次恶化。15 名患者中有 9 名（60%）在癌症治疗后出现耳鸣。对主观听力障碍和残疾（听力测量量表）的评估表明，某些患者在某些情况下听力有很大困难。听力测量量表显示，纯音听力图的结果仅部分与明显的听力困难相关。
在化疗期间和之后，应进行定期的随访听力检查，包括纯音听力图检查和主观听力障碍评估，以确定需要特别关注的患者。这将确保听力受损的个体能够获得最合适的听力设备，以促进良好的言语和社会发展。
