Osmond D G
Department of Anatomy, McGill University, Montreal, Canada.
Semin Immunol. 1990 May;2(3):173-80.
Recent years have produced considerable progress in defining stages in the development of B cells in vivo, and in revealing interactions with regulatory molecules and cells. Studies of the phenotype and population dynamics of precursor B cells in mouse bone marrow have quantitated cell production at sequential steps of differentiation and have also indicated a substantial cell death. The proliferation of precursor B cells is influenced both by systemic factors and by cytokines derived from bone marrow stromal cells. In situ immunolabeling has revealed that early precursor B cells are closely associated with subosteal stromal cells, aberrant B lineage cells appear to be deleted by macrophages and terminal B cells mature within the lumen of vascular sinusoids before being released. The findings lead to working models of the in vivo differentiation, regulation and microenvironmental organization of B cell genesis in the bone marrow.
近年来，在确定体内B细胞发育阶段以及揭示其与调节分子和细胞的相互作用方面取得了显著进展。对小鼠骨髓中前体B细胞的表型和群体动态的研究已经对分化的连续步骤中的细胞产生进行了定量，并且还表明存在大量细胞死亡。前体B细胞的增殖既受全身因素影响，也受骨髓基质细胞衍生的细胞因子影响。原位免疫标记显示，早期前体B细胞与骨膜下基质细胞密切相关，异常B谱系细胞似乎被巨噬细胞清除，终末B细胞在血管窦腔内成熟后才被释放。这些发现形成了骨髓中B细胞发生的体内分化、调节和微环境组织的工作模型。
