Judzentiene Asta, Budiene Jurga, Butkiene Rita, Kupcinskiene Eugenija, Laffont-Schwob Isabelle, Masotti Véronique
Center for Physical Sciences and Technology, Institute of Chemistry, A. Gostauto 9, LT-01108 Vilnius, Lithuania.
Nat Prod Commun. 2010 Dec;5(12):1981-4.
The chemical composition of the essential oils of aerial parts of Artemisia campestris ssp. campestris, collected from ten different locations in Lithuania is detailed in this paper. The major component in all the oils was caryophyllene oxide (8.5-38.8%), whereas compounds with the caryophyllane skeleton ranged from 10.2 to 44.5%. Other representative constituents were germacrene D (< or = 15.0%), humulene epoxide II (< or = 8.1%), beta-ylangene (< or = 7.7%), spathulenol (< or = 6.8%), beta-elemene (< or = 6.8%), beta-caryophyllene (< or = 6.2%), junenol (< or = 6.1%) and alpha- or beta-pinene (< or = 5.5%). Eighty-seven compounds were identified, comprising 73.6-92.3% of the oils. The chemical composition was highly variable depending on the sample location. Toxicity of A. campestris oils was determined using the brine shrimp (Artemia sp.) assay. LC50 values ranging to 20 microg/mL were obtained for three of the oils after 24 hours of exposure. Data of this test revealed that A. campestris ssp. campestris essential oils with dominant caryophyllene oxide are notably toxic.
本文详细介绍了从立陶宛十个不同地点采集的原野蒿（Artemisia campestris ssp. campestris）地上部分精油的化学成分。所有精油中的主要成分是氧化石竹烯（8.5 - 38.8%），而具有石竹烷骨架的化合物含量在10.2%至44.5%之间。其他代表性成分包括杜松烯D（≤15.0%）、环氧葎草烯II（≤8.1%）、β-衣兰烯（≤7.7%）、匙叶桉油烯醇（≤6.8%）、β-榄香烯（≤6.8%）、β-石竹烯（≤6.2%）、杜鹃醇（≤6.1%）和α-或β-蒎烯（≤5.5%）。共鉴定出87种化合物，占精油的73.6 - 92.3%。化学成分因样品采集地点的不同而有很大差异。采用卤虫（Artemia sp.）试验测定了原野蒿精油的毒性。暴露24小时后，三种精油的半数致死浓度（LC50）值达到20微克/毫升。该试验数据表明，以氧化石竹烯为主的原野蒿精油具有显著毒性。
