2005 - 2006年期间，泰国年轻男性中使用IgG捕获BED酶免疫测定法（BED - CEIA）估算的HIV - 1发病率。

HIV-1 incidence estimates among young Thai men using IgG-capture BED-enzyme immunoassay (BED-CEIA) during 2005-2006.

作者信息

Kana Khunakorn, Tabprasit Sutchana, Chuenchitra Thippawan, Sirisopana Narongrid, Rangsin Ram

机构信息

Armed Forces Research Institute of Medical Sciences, Bangkok, Thailand.

出版信息

J Med Assoc Thai. 2009 Feb;92 Suppl 1:S112-6.

PMID:21299183

Abstract

BACKGROUND

Knowledge about the most recent HIV epidemic among young generation in Thailand is crucial for improving the prevention programs. It is important to distinguish between recent and long-term HIV-1 infections among the sero-surveillance populations to estimate the HIV-1 incidence.

OBJECTIVE

To obtain the HIV-1 incidence estimates in young Thai men from the HIV-1 sero-surveillance among the Royal Thai Army (RTA) conscripts inducted between November 2005 and November 2006.

MATERIAL AND METHOD

The confirmed HIV-1 positive serum samples obtained from the November 2005, May 2006, and November 2006 rounds of RTA conscripts induction were selected to be included in the study. The recent HIV-1 infections were detected among the confirmed HIV-1 positive serum samples using an HIV-1 BED incidence EIA Kit (Calypte HIV-1 BED Incidence EIA, Calypte Biomedical Corporation, Maryland, USA. The incidence estimates were obtained in each round of the induction using a consensus formula was agreed upon at the US Centers for Disease Controls and Preventions (CDC).

RESULTS

Eighty seven thousand one hundred seventy eight RTA conscripts were tested for HIV-1 infection between November 2005 and November 2006. The prevalence of HIV-1 infection was 0.51%, 0.60%, and 0.50% for the period of November 2005, May 2006, and November 2006, respectively. The HIV-1 incidence estimates were 0.14%/year (95% CI, 0.09-0.20), 0.20% year (95% CI, 0.13-0.28), and 0.17%/year (95% CI, 0.10-0.29) in November 2005, May 2006, and November 2006, respectively.

CONCLUSION

We reported the HIV-1 incidence estimates obtained from the IgG-capture BED-enzyme immunoassay (BED-CEIA) method in the RTA conscripts sero-surveillance population. The incidence estimates were ranging from 0.14% - 0.20%/year between November 2005 and November 2006. The estimates could serve as the recent baseline information for future HIV prevention interventions in Thailand.

摘要

背景

了解泰国年轻一代中最新的艾滋病流行情况对于改进预防计划至关重要。在血清监测人群中区分近期和长期的HIV-1感染对于估计HIV-1发病率很重要。

目的

通过对2005年11月至2006年11月应征入伍的泰国皇家军队（RTA）新兵进行HIV-1血清监测，获得泰国年轻男性的HIV-1发病率估计值。

材料与方法

从2005年11月、2006年5月和2006年11月三轮RTA新兵入伍时获得的确诊HIV-1阳性血清样本被选入研究。使用HIV-1 BED发病率酶免疫分析试剂盒（Calypte HIV-1 BED发病率酶免疫分析，Calypte生物医学公司，美国马里兰州）在确诊的HIV-1阳性血清样本中检测近期HIV-1感染。使用美国疾病控制与预防中心（CDC）商定的共识公式在每一轮入伍时获得发病率估计值。

结果

2005年11月至2006年11月期间，对87178名RTA新兵进行了HIV-1感染检测。2005年11月、2006年5月和2006年11月期间，HIV-1感染率分别为0.51%、0.60%和0.50%。2005年11月、2006年5月和2006年11月的HIV-1发病率估计值分别为0.14%/年（95%CI，0.09-0.20）、0.20%/年（95%CI，0.13-0.28）和0.17%/年（95%CI，0.10-0.29）。