Jiang Yan, Wang Minjie, Ni Mingjian, Duan Song, Wang Yulin, Feng Jigang, Xiao Yao, Dong Yonghui, Wang Dongli, Han Mei, Xiang Lifen, Ma Luoyun, Zhou Quanhua
National AIDS Reference Laboratory, National Center for AIDS/STD Control and Prevention, Beijing, China.
AIDS. 2007 Dec;21 Suppl 8:S47-51. doi: 10.1097/01.aids.0000304696.62508.8a.
To detect recent infection in injection drug users (IDU) using the HIV-1 subtypes B, E, and D IgG-capture enzyme immunoassay (BED-CEIA) and estimate HIV-1 incidence in the IDU population in three cities of China.
HIV-1-positive samples from IDU surveillance sentinel sites were collected for BED-CEIA, including 215 from city C (2001-2006), 433 from city D (2005), and 912 from city E (2000-2003). All 1560 samples were confirmed HIV positive with Western blot or alternative strategy.
HIV-1 incidence was calculated with BED-CEIA statistics software.
City C: Annualized HIV-1 incidence among IDU of surveillance sentinel sites was 0.57-0.93% from 2000 to 2001, and approximately 1.0% from 2004 to 2006. City D: In IDU surveillance sentinel sites in 2005, the HIV-1 incidence was estimated to be 9.6%, whereas the incidence in all drug users was 2.1%. City E: IDU sentinel surveillance indicated a slight decrease in HIV-1 incidence from 9.2% in 2000 to 7.9% in 2003.
The HIV-1 incidence in IDU in city C was stable and relatively low. In contrast, there is a high HIV-1 incidence among IDU in cities D and E. The adjusted BED-CEIA estimated incidence rates indicate clearly that interventions must be strengthened continuously in IDU, especially in two Chinese cities.
采用HIV-1 B、E和D亚型IgG捕获酶免疫分析法（BED-CEIA）检测注射吸毒者（IDU）近期感染情况，并估算中国三个城市IDU人群中的HIV-1发病率。
收集来自IDU监测哨点的HIV-1阳性样本进行BED-CEIA检测，其中包括来自城市C的215份样本（2001 - 2006年）、来自城市D的433份样本（2005年）以及来自城市E的912份样本（2000 - 2003年）。所有1560份样本均经免疫印迹法或其他方法确认为HIV阳性。
使用BED-CEIA统计软件计算HIV-1发病率。
城市C：2000年至2001年，监测哨点IDU中HIV-1年化发病率为0.57% - 0.93%，2004年至2006年约为1.0%。城市D：2005年，IDU监测哨点中HIV-1发病率估计为9.6%，而所有吸毒者中的发病率为2.1%。城市E：IDU哨点监测显示HIV-1发病率从2000年的9.2%略有下降至2003年的7.9%。
城市C的IDU中HIV-1发病率稳定且相对较低。相比之下，城市D和E的IDU中HIV-1发病率较高。经调整的BED-CEIA估计发病率清楚地表明，必须持续加强对IDU的干预措施，尤其是在中国的这两个城市。
