与正常孕妇相比，子痫前期患者的视黄醇结合蛋白-4 降低。
Retinol-binding protein-4 is decreased in patients with preeclampsia in comparison with normal pregnant women.
机构信息
Department of Obstetrics and Gynecology, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Korea.
出版信息
J Perinat Med. 2011 May;39(3):287-9. doi: 10.1515/jpm.2011.016. Epub 2011 Feb 7.
AIMS
The aim of this study was to investigate retinol-binding protein-4 (RBP4) levels in maternal and umbilical cord serum in patients in the third trimester of pregnancy with preeclampsia in comparison to levels in normal pregnant women.
METHODS
The RBP4 levels in maternal and umbilical cord serum were measured and compared by enzyme-linked immunosorbent assay in 16 normal pregnant and 16 patients with preeclampsia.
RESULTS
Both maternal and umbilical cord serum RBP4 levels were significantly decreased in patients with preeclampsia, as compared to normal pregnant women (maternal serum, median 168.0 μg/mL vs. 202.0 μg/mL, P<0.001; umbilical cord serum, median 147.9 μg/mL vs. 193.0 μg/mL, P<0.001). Preeclampsia was independently related to RBP4 levels of maternal and umbilical cord serum.
CONCLUSION
Both maternal and umbilical cord serum RBP4 levels were lower in patients with preeclampsia than in normal pregnant women in the third trimester of pregnancy.
目的
本研究旨在探讨子痫前期孕妇妊娠晚期血清视黄醇结合蛋白 4（RBP4）水平，并与正常孕妇进行比较。
方法
采用酶联免疫吸附试验检测 16 例正常孕妇和 16 例子痫前期孕妇的血清 RBP4 水平。
结果
与正常孕妇相比，子痫前期患者血清 RBP4 水平明显降低（母血清，中位数 168.0μg/ml 比 202.0μg/ml，P<0.001；脐血清，中位数 147.9μg/ml 比 193.0μg/ml，P<0.001）。子痫前期与母血清和脐血清 RBP4 水平独立相关。
结论
与妊娠晚期正常孕妇相比，子痫前期患者母血清和脐血清 RBP4 水平均降低。
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