Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Psychiatry Res. 2011 Jun 30;188(1):129-32. doi: 10.1016/j.psychres.2011.01.010. Epub 2011 Feb 5.
We have recently found that consanguinity is a risk factor for bipolar I disorder (BP1) and schizophrenia (SZ) in Egypt. Inbreeding has been associated with increased cellular stress and impaired physiological function in plants and animals. Previous studies have reported that telomere length (TL), an index of oxidative stress and cellular senescence is significantly reduced among patients with SZ or mood disorders compared with control individuals. Hence we evaluated TL as a possible mediator of the observed association between consanguinity and BP1/SZ risk. Patients with BP1 (n=108), or SZ (n=60) were compared with screened adult controls in separate experiments. TL was estimated using a quantitative PCR (qPCR) based assay. The inbreeding coefficient/consanguinity rate was estimated in two ways: using 64 DNA polymorphisms ('DNA-based' rate); and from family history data ('self report'). Significant correlation between TL and DNA based inbreeding was not observed overall, though suggestive trends were present among the SZ cases. No significant case-control differences in TL were found after controlling for demographic variables. In conclusion, reduced TL may not explain a significant proportion of observed associations between consanguinity and risk for BP1/SZ.
我们最近发现近亲结婚是埃及双相情感障碍（BP1）和精神分裂症（SZ）的一个风险因素。近亲繁殖与植物和动物的细胞应激增加和生理功能受损有关。先前的研究报告称，与对照组个体相比，精神分裂症或心境障碍患者的端粒长度（TL），即氧化应激和细胞衰老的指标明显降低。因此，我们评估了 TL 是否可能是近亲结婚与 BP1/SZ 风险之间观察到的关联的中介。在单独的实验中，将 BP1（n=108）或 SZ（n=60）患者与筛查的成年对照组进行比较。使用基于定量 PCR（qPCR）的测定法估计 TL。使用 64 个 DNA 多态性（“基于 DNA”的比率）和家族史数据（“自我报告”）以两种方式估计近亲系数/近亲结婚率。尽管在 SZ 病例中存在提示性趋势，但总体上未观察到 TL 与基于 DNA 的近亲结婚之间存在显著相关性。在控制人口统计学变量后，未发现 TL 在 TL 上存在显著的病例对照差异。总之，TL 的降低可能不能解释近亲结婚与 BP1/SZ 风险之间观察到的关联的很大一部分。
