Department of Biophysics, Poznań University of Medical Sciences, Poznań, Poland.
Colloids Surf B Biointerfaces. 2011 May 1;84(1):131-4. doi: 10.1016/j.colsurfb.2010.12.026. Epub 2011 Jan 19.
This paper reports on the effect of paracetamol on the dielectric behavior of the rabbit lens. Measurements were performed over the frequency range of 100 Hz-100 kHz in air and at the temperature of 35°C. The frequency dependencies of the relative permittivity and dielectric loss for the control and paracetamol-control lenses are described in terms of a power-low, Debye and Cole-Cole relations. The effect of paracetamol on the dielectric properties of the lens is visible in the lower values of the relative permittivity than those for the control sample at the same frequency. In addition, the relaxations around 18 and 46 kHz for the paracetamol-control lens are shifted to lower frequencies compared with the control lens. The results of this work indicate that the present method is useful in detection of the lens toxicity elicited by overdoses of paracetamol in animal.
本文报告了对乙酰氨基酚对兔晶状体介电行为的影响。在空气和 35°C 的温度下，在 100Hz-100kHz 的频率范围内进行了测量。用幂律、德拜和科尔-科尔关系描述了对照和对乙酰氨基酚对照晶状体的相对介电常数和介电损耗的频率依赖性。与同一频率下的对照样品相比，对乙酰氨基酚对晶状体介电性能的影响表现为相对介电常数较低。此外，与对照晶状体相比，对乙酰氨基酚对照晶状体在 18 和 46kHz 附近的弛豫向较低频率移动。本工作的结果表明，本方法可用于检测动物过量服用对乙酰氨基酚引起的晶状体毒性。
