Cardeñosa Neus, Rodés Anna, Follia Núria, Plasencia Elsa, Lafuente Sarah, Arias César, Torra Roser, Minguell Sofia, Ferrús Glòria, Barrabeig Irene, Godoy Pere
General Directorate of Public Health, Department of Health, Generalitat of Catalonia, Barcelona, Spain.
Hum Vaccin. 2011 Jan-Feb;7 Suppl:226-9. doi: 10.4161/hv.7.0.14609. Epub 2011 Jan 1.
From 25th April 2009 to 20th January 2010, 771 laboratory confirmed cases of 2009 pandemic influenza A (H1N1) were admitted to intensive care units (ICU) or hospitalized in medical wards with clinical criteria of severe disease (hospitalized pneumonias, multiorganic failure, septic shock or admitted to ICU or death while hospitalized). 82% of cases were hospitalized between epidemiological week 43 and 48 (25th October - 5th December 2009). Median age of patients was 40 years (range 0-89 years) and 56% were males. 38.7% cases were in the 15-44 year age-group, 29.4% in the 45-64 and 21.8% were children under 15 years of age. 36.8% were admitted to an ICU and 48 died. Underlying conditions were absent in 29% of patients (up to 38% among those under 15 years old). Differences in the prevalence of underlying conditions were found between children and adults. In children less than 15 years old, asthma (16.2%), other respiratory diseases (12.7%), cognitive disorders (10.2%), epilepsy (8.7%) and neuromuscular disorders (7.1%) were the most frequent. In adults, chronic obstructive pulmonary disease (14.8%), cardiovascular diseases (12.6%), asthma (11.5%), diabetes (11.2%) and morbid obesity (10.6%) were the most frequent. Further surveillance is needed to better characterize the epidemiology of this pandemic.
2009年4月25日至2010年1月20日，771例实验室确诊的2009年甲型H1N1大流行性流感病例因符合重症疾病临床标准（住院肺炎、多器官功能衰竭、感染性休克或入住重症监护病房或住院期间死亡）而入住重症监护病房（ICU）或在普通病房住院。82%的病例在第43至48流行病学周（2009年10月25日至12月5日）期间住院。患者的中位年龄为40岁（范围0至89岁），56%为男性。38.7%的病例年龄在15至44岁之间，29.4%在45至64岁之间，21.8%为15岁以下儿童。36.8%的患者入住了重症监护病房，48例死亡。29%的患者无基础疾病（15岁以下患者中这一比例高达38%）。儿童和成人基础疾病的患病率存在差异。在15岁以下儿童中，哮喘（16.2%）、其他呼吸系统疾病（12.7%）、认知障碍（10.2%）、癫痫（8.7%）和神经肌肉疾病（7.1%）最为常见。在成人中，慢性阻塞性肺疾病（14.8%）、心血管疾病（12.6%）、哮喘（11.5%）、糖尿病（11.2%）和病态肥胖（10.6%）最为常见。需要进一步监测以更好地描述这一大流行的流行病学特征。
