Harry S. Truman Memorial Veterans' Hospital, Columbia, MO, USA.
J Nucl Cardiol. 2011 Apr;18(2):309-13. doi: 10.1007/s12350-011-9344-5. Epub 2011 Feb 8.
BACKGROUND/AIM: We noticed that there was decreased correlation of the findings from myocardial perfusion imaging (MPI) and cardiac catheterization (CATH) in patients with mitral regurgitation (MR) and aortic regurgitation (AR) compared to patients without valve disease.
Through a systematic review of MPI records at the Harry S. Truman Memorial Veterans' Hospital between 1998 and 2008, we identified 58 patients with at least moderate MR or AR by echocardiogram who underwent cardiac catheterization within 6 months of the MPI study. A control group was formulated with 60 patients who did not have significant MR or AR on echocardiogram and who had both MPI and CATH. Correlation between MPI and CATH was graded as complete, partial, or absent.
Correlation between MPI and CATH was lower in the valve disease patients (study group) when compared to controls. Correlation was complete in 76% of study patients and 90% of controls, partial in 15% of study patients and 5% of controls, and absent in 9% of study patients and 5% of controls. Differences between the groups were significant (P < .05).
Patients with regurgitant valvular heart disease may have myocardial perfusion abnormalities that are not associated with angiographic critical coronary stenosis.
背景/目的：我们注意到，与无瓣膜疾病的患者相比，患有二尖瓣反流（MR）和主动脉瓣反流（AR）的患者，其心肌灌注成像（MPI）和心导管检查（CATH）的结果相关性降低。
通过对 1998 年至 2008 年期间哈里·S·杜鲁门纪念退伍军人医院的 MPI 记录进行系统回顾，我们确定了 58 例经超声心动图诊断为至少中度 MR 或 AR 的患者，这些患者在 MPI 研究后 6 个月内接受了心导管检查。对照组由 60 例超声心动图无明显 MR 或 AR 且同时接受 MPI 和 CATH 的患者组成。MPI 和 CATH 的相关性分为完全、部分和无相关性。
与对照组相比，瓣膜疾病患者（研究组）的 MPI 和 CATH 相关性较低。研究组中完全相关的患者占 76%，对照组为 90%；部分相关的患者占 15%，对照组为 5%；无相关性的患者占 9%，对照组为 5%。组间差异具有统计学意义（P<.05）。
患有反流性瓣膜性心脏病的患者可能存在与血管造影临界冠状动脉狭窄无关的心肌灌注异常。
