Department of Biology, University of California, 92093, San Diego, La Jolla, California.
Immunogenetics. 1978 Dec;7(1):537-43. doi: 10.1007/BF01844042.
The antigens Ala-1 and Ly-6 were first thought to be different on the grounds that Ala-1 was present only on activated T and B lymphocytes while Ly-6 was present only on post-thymic T lymphocytes. In this paper, it is shown that Ly-6 is expressed on activated B cells, including PFC and LPS blasts, and that after typing of several recombinant inbred lines,Ala-1 andLy-6 remain genetically inseparable. Based on available data, it is most likely that Ly-6 is in fact Ala-1, although further testing is required to confirm the absence of Ly-6 from nonactivated lymphocytes.
抗原 Ala-1 和 Ly-6 最初被认为是不同的,因为 Ala-1 仅存在于活化的 T 和 B 淋巴细胞上,而 Ly-6 仅存在于胸腺后 T 淋巴细胞上。本文表明,Ly-6 表达于活化的 B 细胞上,包括 PFC 和 LPS 母细胞,并且在对几个重组近交系进行分型后,Ala-1 和 Ly-6 仍然在遗传上不可分离。根据现有数据,最有可能的是 Ly-6 实际上就是 Ala-1,尽管需要进一步的测试来确认非活化淋巴细胞中不存在 Ly-6。