Muramatsu Toshinari, Yoshitake Tomoko, Iida Tetsuji, Yamashita Eiko, Hirasawa Takeshi, Miyamoto Tsuyoshi, Murakami Masaru, Matsui Naruaki, Kajiwara Hiroshi, Yasuda Masanori, Osamura R Yoshiyuki, Mikami Mikio
Department of Obstetrics and Gynecology, Tokai University School of Medicine, Shimokasuya 143, Isehara, Kanagawa 259-1143, Japan.
Tokai J Exp Clin Med. 2006 Dec 20;31(4):141-5.
During the five-year period from January 1997 to December 2001, cytological abnormalities in the uterine cervix were confirmed in 189 women (class IIIa: 172, class IIIb: 9, class IV: 7, and class V: 1) who underwent cytology screening of the uterine cervix at the Tokai University Health Evaluation and Promotion Center. Biopsy samples from the uterine cervix showed that the 172 women categorized into class IIIa based on cytology included 28 with no atypical lesions, 53 with mild dysplasia, 24 with moderate dysplasia, 3 with severe dysplasia; and the 9 women in class IIIb included 2 with mild dysplasia, 5 with moderate dysplasia, 1 with carcinoma in situ, and 1 with invasive carcinoma. The conformity rates between the cytology data and the biopsy samples were 71.3% and 11.1% in class IIIa and class IIIb, respectively. A three-year followup survey of the class IIIa and class IIIb subjects confirmed progression (PRO) in 8 (4.7%), continuous (CON) symptoms in 48 (27.9%), and regression (REG) in 116 (67.4%) in class IIIa, and PRO, CON and REG in 3 (33.3%), 4 (44.4%), and 2 (22.2%), respectively, in class IIIb; the percentage of subjects in the CON+REG group was significantly higher than in the PRO group (p = 0.0052). Twelve subjects underwent resection because uterine carcinoma was suspected in the punch biopsy; these subjects have remained under observation and have now made a complete recovery. Our results suggest that patients with uterine abnormal cells should undergo regular cytology and colposcopy for detection of high-risk patients and to allow treatment at an early stage.
在1997年1月至2001年12月的五年期间，东海大学健康评估与促进中心对189名接受子宫颈细胞学筛查的女性确诊了子宫颈细胞学异常（IIIa级：172例，IIIb级：9例，IV级：7例，V级：1例）。子宫颈活检样本显示，根据细胞学分类为IIIa级的172名女性中，28例无非典型病变，53例轻度发育异常，24例中度发育异常，3例重度发育异常；IIIb级的9名女性中，2例轻度发育异常，5例中度发育异常，1例原位癌，1例浸润癌。IIIa级和IIIb级细胞学数据与活检样本的符合率分别为71.3%和11.1%。对IIIa级和IIIb级受试者进行的为期三年的随访调查证实，IIIa级中有8例（4.7%）病情进展（PRO），48例（27.9%）症状持续（CON），116例（67.4%）病情消退（REG）；IIIb级中PRO、CON和REG分别为3例（33.3%）、4例（44.4%）和2例（22.2%）；CON + REG组受试者的百分比显著高于PRO组（p = 0.0052）。12名受试者因穿刺活检怀疑子宫癌而接受了切除术；这些受试者一直在接受观察，现已完全康复。我们的结果表明，子宫细胞异常的患者应定期进行细胞学和阴道镜检查，以检测高危患者并在早期进行治疗。
