Schück O, Taplan V, Nádvorníková H
Institute for Clinical and Experimental Medicine, Prague, Czechoslovakia.
Nephrol Dial Transplant. 1990;5(7):549-50. doi: 10.1093/ndt/5.7.549.
In a group of 16 patients on regular haemodialysis treatment, inulin and creatinine clearance was examined before and 12 h after haemodialysis. Inulin clearance (CIn) decreased significantly (P less than 0.001) whereas creatinine clearance (CCr) did not change after haemodialysis. The CCr/CIn ratio increased significantly (P less than 0.05) as did calculated tubular secretion of creatinine (TCr) (P less than 0.01) and TCr/CIn 100 (P less than 0.001). The results suggest that uraemic sera contain dialysable substance(s) depressing tubular secretion of creatinine.
在一组16名接受定期血液透析治疗的患者中，在血液透析前和透析后12小时检测了菊粉清除率和肌酐清除率。血液透析后菊粉清除率（CIn）显著降低（P<0.001），而肌酐清除率（CCr）没有变化。CCr/CIn比值显著升高（P<0.05），计算得出的肌酐肾小管分泌量（TCr）也显著升高（P<0.01），TCr/CIn 100同样显著升高（P<0.001）。结果表明，尿毒症血清中含有可透析物质，可抑制肌酐的肾小管分泌。
