Feber J, Schärer K, Schaefer F, Míková M, Janda J
Division of Paediatric Nephrology, University Children's Hospital Heidelberg, Germany.
Pediatr Nephrol. 1994 Oct;8(5):579-83. doi: 10.1007/BF00858132.
Residual renal function was studied in 28 haemodialysis (HD) and 31 peritoneal dialysis (PD) patients aged 1-20 years observed over 6-43 (median 19) months. After the start of dialysis urine volume (UV) decreased to 57%, 46% and 26% of initial mean values in HD patients after 6, 12 and 24 months, respectively. In PD patients the corresponding figures were 57%, 69% and 62%. Mean UV calculated from all individual mean UV measurements observed was higher in PD than HD patients (954 vs. 537 ml/m2 per 24 h, P < 0.01). A better conservation of diuresis in PD patients was also suggested by a significantly longer persistence of a UV greater than 500 ml/m2 per 24 h compared with HD patients. Cox proportional hazard analysis identified dialysis modality and pre-dialysis UV of less than 1,000 ml/m2 per 24 h as the only significant risk factors for UV survival. However, the decline of UV per time was similar in both modes of treatment. No significant changes of glomerular filtration rate were observed during both HD and PD treatment.
对28例年龄在1至20岁的血液透析（HD）患者和31例腹膜透析（PD）患者的残余肾功能进行了研究，观察时间为6至43个月（中位数为19个月）。透析开始后，HD患者在6个月、12个月和24个月时的尿量（UV）分别降至初始平均值的57%、46%和26%。PD患者的相应数字分别为57%、69%和62%。根据观察到的所有个体平均UV测量值计算得出的平均UV，PD患者高于HD患者（每24小时954 vs. 537 ml/m²，P < 0.01）。与HD患者相比，PD患者每24小时UV大于500 ml/m²的持续时间显著更长，这也表明PD患者的利尿功能保留得更好。Cox比例风险分析确定透析方式和透析前UV低于每24小时1000 ml/m²是UV存活的唯一显著风险因素。然而，两种治疗方式下UV随时间的下降情况相似。在HD和PD治疗期间均未观察到肾小球滤过率的显著变化。
