HIV 感染者药物使用者的老龄化和共病相关趋势。

Trends related to aging and co-occurring disorders in HIV-infected drug users.

机构信息

Division of Infectious Diseases and Disease Prevention and Public Health Institute, The Mount Sinai School of Medicine, New York, New York 10029, USA.

出版信息

Subst Use Misuse. 2011;46(2-3):233-44. doi: 10.3109/10826084.2011.522843.

DOI:10.3109/10826084.2011.522843

PMID:21303243

Abstract

Drug users with HIV infection successfully treated with highly active antiretroviral therapy are now living to older ages. As persons with HIV infection age, they become at risk for comorbidities that occur in any group of aging individuals. However, some of these conditions occur at increased rates, with increasing severity, or pose special problems in older persons with HIV infection. This article discusses the epidemiology of HIV infection in aging drug users, and hormonal, cardiovascular, liver, renal, bone, and cognitive disorders and depression and cancer in these individuals, as well as problems related to taking multiple medications and HIV disease progression.

摘要

接受高效抗逆转录病毒治疗的 HIV 感染吸毒者现在已能存活至老年。随着 HIV 感染者年龄的增长，他们有罹患任何老年人群中都可能发生的合并症的风险。然而，在 HIV 感染的老年人群中，这些情况中的一些以更高的速率、更严重的程度发生，或造成特殊问题。本文讨论了老年吸毒者中 HIV 感染的流行病学，以及这些人群中的激素、心血管、肝脏、肾脏、骨骼和认知障碍以及抑郁和癌症，以及与服用多种药物和 HIV 疾病进展相关的问题。