LG Household and Health Care Co., Ltd., Daejeon, Korea.
J Med Food. 2011 Apr;14(4):334-43. doi: 10.1089/jmf.2009.1374. Epub 2011 Feb 8.
A combination of green tea extract and l-theanine (LGNC-07) has been reported to have beneficial effects on cognition in animal studies. In this randomized, double-blind, placebo-controlled study, the effect of LGNC-07 on memory and attention in subjects with mild cognitive impairment (MCI) was investigated. Ninety-one MCI subjects whose Mini Mental State Examination-K (MMSE-K) scores were between 21 and 26 and who were in either stage 2 or 3 on the Global Deterioration Scale were enrolled in this study. The treatment group (13 men, 32 women; 57.58 ± 9.45 years) took 1,680 mg of LGNC-07, and the placebo group (12 men, 34 women; 56.28 ± 9.92 years) received an equivalent amount of maltodextrin and lactose for 16 weeks. Neuropsychological tests (Rey-Kim memory test and Stroop color-word test) and electroencephalography were conducted to evaluate the effect of LGNC-07 on memory and attention. Further analyses were stratified by baseline severity to evaluate treatment response on the degree of impairment (MMSE-K 21-23 and 24-26). LGNC-07 led to improvements in memory by marginally increasing delayed recognition in the Rey-Kim memory test (P = .0572). Stratified analyses showed that LGNC-07 improved memory and selective attention by significantly increasing the Rey-Kim memory quotient and word reading in the subjects with MMSE-K scores of 21-23 (LGNC-07, n = 11; placebo, n = 9). Electroencephalograms were recorded in 24 randomly selected subjects hourly for 3 hours in eye-open, eye-closed, and reading states after a single dose of LGNC-07 (LGNC-07, n = 12; placebo, n = 12). Brain theta waves, an indicator of cognitive alertness, were increased significantly in the temporal, frontal, parietal, and occipital areas after 3 hours in the eye-open and reading states. Therefore, this study suggests that LGNC-07 has potential as an intervention for cognitive improvement.
绿茶提取物和 L-茶氨酸（LGNC-07）的组合已被报道在动物研究中对认知具有有益影响。在这项随机、双盲、安慰剂对照研究中，研究了 LGNC-07 对轻度认知障碍（MCI）患者记忆和注意力的影响。共有 91 名 MCI 患者入组本研究，他们的 Mini 精神状态检查-K（MMSE-K）评分在 21-26 之间，且在全球衰退量表上处于 2 期或 3 期。治疗组（13 名男性，32 名女性；57.58±9.45 岁）服用 1680 毫克 LGNC-07，安慰剂组（12 名男性，34 名女性；56.28±9.92 岁）服用等量的麦芽糊精和乳糖，共 16 周。进行神经心理学测试（ Rey-Kim 记忆测试和 Stroop 颜色词测试）和脑电图，以评估 LGNC-07 对记忆和注意力的影响。进一步按基线严重程度分层，以评估在损害程度（MMSE-K 21-23 和 24-26）上的治疗反应。LGNC-07 导致记忆的改善，通过 Rey-Kim 记忆测试中延迟识别的适度增加（P=0.0572）。分层分析显示，LGNC-07 通过显著增加 Rey-Kim 记忆商和单词阅读，改善了 MMSE-K 评分在 21-23 分的患者的记忆和选择性注意力（LGNC-07，n=11；安慰剂，n=9）。在单次服用 LGNC-07 后，24 名随机选择的受试者在睁眼、闭眼和阅读状态下每小时记录 3 小时的脑电图。在睁眼和阅读状态下 3 小时后，脑 theta 波（认知警觉性的指标）在颞叶、额叶、顶叶和枕叶区域显著增加。因此，本研究表明 LGNC-07 具有改善认知的潜力。
