Walsh John, Roberts Ruth, Bailey Timothy
Advanced Metabolic Care + Research, Escondido, California 92026, USA.
J Diabetes Sci Technol. 2011 Jan 1;5(1):129-35. doi: 10.1177/193229681100500118.
Bolus insulin calculators (BCs) became available in insulin pumps in 2002 and are being integrated into glucose meters and portable device applets for use with multiple daily injections. A retrospective analysis of continuous subcutaneous insulin infusion data from the Actual Pump Practices (APP) study is used in this article to generate formulas for more precise BC settings. A well-designed BC determines accurate bolus doses for carbohydrate intake and for correcting elevated glucose levels. It should also provide the logic necessary to track residual bolus insulin and reduce bolus recommendations to minimize insulin stacking. To provide appropriate bolus doses, a BC requires accurate settings for the carbohydrate factor or insulin:carbohydrate ratio, glucose correction factor, duration of insulin action, and correction target. We provide guidelines to select BC settings from the user's current total daily dose (TDD) of insulin and to determine more appropriate BC settings from an improved TDD based on the mean glucose level.
大剂量胰岛素计算器（BCs）于2002年开始应用于胰岛素泵，并正被整合到血糖仪和便携式设备小程序中，以便用于多次皮下注射。本文采用对实际泵使用情况（APP）研究中的持续皮下胰岛素输注数据进行回顾性分析，来生成用于更精确BC设置的公式。设计良好的BC能为碳水化合物摄入量和纠正血糖升高确定准确的大剂量胰岛素剂量。它还应提供追踪残余大剂量胰岛素以及减少大剂量建议以尽量减少胰岛素叠加所需的逻辑。为了提供合适的大剂量胰岛素剂量，BC需要针对碳水化合物因子或胰岛素：碳水化合物比值、血糖校正因子、胰岛素作用持续时间和校正目标进行准确设置。我们提供了从用户当前的每日胰岛素总剂量（TDD）中选择BC设置的指南，并根据平均血糖水平从改进的TDD中确定更合适的BC设置。
