Department of Gastroenterology & Hepatology, Vrije Universiteit University Medical Center, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands.
Nat Rev Gastroenterol Hepatol. 2011 Mar;8(3):169-77. doi: 10.1038/nrgastro.2011.4. Epub 2011 Feb 8.
More research is now focused on pancreatic steatosis. Multiple definitions, clinical associations and synonyms for pancreatic steatosis are described in the literature and can be confusing. The integration and comparison of several studies concerning this topic is therefore challenging. In the past, pancreatic steatosis was considered an innocuous condition, a bystander of many underlying diseases (such as congenital syndromes, hemochromatosis and viral infection). However, evidence that pancreatic steatosis (strongly associated with obesity and the metabolic syndrome) has a role in type 2 diabetes mellitus, pancreatic exocrine dysfunction, acute pancreatitis, pancreatic cancer and the formation of pancreatic fistula after pancreatic surgery is emerging. This Review focuses on the different etiological factors and the clinical consequences of pancreatic steatosis.
目前，研究的重点更多地集中在胰腺脂肪变性上。文献中描述了胰腺脂肪变性的多种定义、临床关联和同义词，这可能会令人困惑。因此，整合和比较几个关于这个主题的研究是具有挑战性的。过去，胰腺脂肪变性被认为是一种无害的情况，是许多潜在疾病（如先天性综合征、血色病和病毒感染）的旁观者。然而，有证据表明，胰腺脂肪变性（与肥胖和代谢综合征密切相关）与 2 型糖尿病、胰腺外分泌功能障碍、急性胰腺炎、胰腺癌以及胰腺手术后胰瘘的形成有关。这篇综述重点介绍了胰腺脂肪变性的不同病因因素和临床后果。
