药物遗传学：类风湿关节炎的抗 TNF 治疗——迈向个体化医疗？
Pharmacogenetics: Anti-TNF therapy in RA--towards personalized medicine?
机构信息
Departments of Pathology and Rheumatology, Section of Inflammatory Disease Profiling, VU University Medical Center, Amsterdam, The Netherlands.
出版信息
Nat Rev Rheumatol. 2011 Mar;7(3):136-8. doi: 10.1038/nrrheum.2011.13. Epub 2011 Feb 8.
PMID:21304506
Abstract
A substantial proportion of patients with rheumatoid arthritis do not respond to tumor necrosis factor blocking therapy. Results of a large genome-wide association study demonstrate evidence of novel genetic factors that determine response to treatment, which could provide a basis for individualizing therapy.
摘要
相当一部分类风湿关节炎患者对肿瘤坏死因子阻断治疗无反应。一项大型全基因组关联研究的结果表明，存在确定治疗反应的新型遗传因素的证据，这可能为个体化治疗提供依据。
Zotero 插件