Palmieri Beniamino, Lodi Daniele, Capone Stefania
Department of General Surgery and Surgical Specialties, University of Modena and Reggio Emilia Medical School, Surgical Clinic, Modena, Italy.
Acta Biomed. 2010 Sep;81(2):94-100.
This review describes intra-articular drugs therapy of arthritis and degenerative joint disease) with a range of old and recent molecules with specific focus on hyaluronic acid. HA is a cartilage matrix basic component secreted by chondrocytes: it prevents cartilage degradation by a complex interpherence between metalloproteinases, pain mediators and cells. Local injections of HA improve functional activity and pain management, particularly when it is combined with other selected drugs.
本综述描述了关节炎和退行性关节疾病的关节内药物治疗，涉及一系列新旧药物分子，并特别关注透明质酸。透明质酸是软骨细胞分泌的软骨基质基本成分：它通过金属蛋白酶、疼痛介质和细胞之间的复杂相互作用来防止软骨降解。局部注射透明质酸可改善功能活动和疼痛管理，尤其是与其他选定药物联合使用时。
