强化胰岛素治疗可适度降低 2 型糖尿病患者的脂联素及其高分子量形式，但对 1 型糖尿病患者无影响。
Intensifying glycaemic control with insulin reduces adiponectin and its HMW isoform moderately in type 2, but not in type 1, diabetes.
机构信息
Service de Diabétologie, Endocrinologie et Nutrition, Hôpital Bichat, Assistance publique des Hôpitaux de Paris, 46, rue Henri-Huchard, 75877 Paris cedex 18, France.
出版信息
Diabetes Metab. 2011 Jun;37(3):259-61. doi: 10.1016/j.diabet.2010.12.001. Epub 2011 Feb 8.
INTRODUCTION
As the impact of diabetes control was not tested on adiponectin (ADPN) levels, this study was designed to assess whether or not controlling hyperglycaemia can affect ADPN.
PATIENTS AND METHODS
A total of 15 T1D and 48 T2D patients with HbA(1c) greater than 10% were studied at the time of hospitalization for uncontrolled diabetes. Total, and high-, medium- and low-molecular-weight (HMW, MMW, LMW) ADPN were measured at the time of study inclusion, on days 1 and 8, and at 1, 3 and 6 months after insulin treatment.
RESULTS
While diabetes control improved, total and HMW APDN decreased on days 1 and 8, but remained steady thereafter in T2D patients. In T1D patients, ADPN levels remained unchanged throughout the study.
CONCLUSION
Glycaemic control with insulin reduces ADPN in T2D patients in the short-term, but was ineffective in T1D.
简介
由于糖尿病控制对脂联素（ADPN）水平的影响尚未得到检验，因此本研究旨在评估控制高血糖是否会影响 ADPN。
患者和方法
共纳入 15 例 T1D 和 48 例 T2D 患者，入院时血糖控制不佳，HbA1c ＞10%。在研究纳入时、第 1 天和第 8 天，以及胰岛素治疗后 1、3 和 6 个月，测定总 ADPN 及高、中、低分子量（HMW、MMW、LMW）ADPN。
结果
随着糖尿病控制的改善，T2D 患者在第 1 天和第 8 天总 ADPN 和 HMW ADPN 下降，但此后保持稳定。而在 T1D 患者中，ADPN 水平在整个研究过程中保持不变。
结论
胰岛素控制血糖在短期内降低 T2D 患者的 ADPN，但对 T1D 无效。
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