Department of Toxicology and Carcinogenesis, Nofer Institute of Occupational Medicine, Łódź, Poland.
Int J Occup Med Environ Health. 2010;23(4):385-9. doi: 10.2478/v10001-010-0026-3.
The aim of the study was to evaluate the toxicokinetics of 2-methylnaphtalene (2-MN) during and after inhalation exposure.
Male Wistar rats were exposed to 2-MN vapours at nominal concentrations of 200 or 400 mg/m3 in the dynamic inhalation chamber for 6 hours or 5 days (6 h/day). Blood samples were collected during and after exposure. Blood concentrations of 2-MN were estimated by gas chromatography using the headspace technique.
During a 6-hour exposure to 200 or 400 mg/m3, blood 2-MN concentration increased rapidly within the first or second hour of exposure, respectively, after reaching a plateau. The elimination of 2-MN from blood followed an open two-compartment model.
2-MN was rapidly eliminated from blood of the animals exposed by inhalation to 2-MN. During exposure, lung retention of the chemical was found to decrease. Under conditions of repeated 2-MN exposure, no significant systemic 2-MN accumulation could be observed.
本研究旨在评估 2-甲基萘（2-MN）在吸入暴露期间和之后的毒代动力学。
雄性 Wistar 大鼠在动态吸入室中以 200 或 400mg/m3 的名义浓度暴露于 2-MN 蒸气中 6 小时或 5 天（每天 6 小时）。暴露期间和之后采集血样。采用顶空气相色谱法测定血样中 2-MN 的浓度。
在 200 或 400mg/m3 的 6 小时暴露期间，血 2-MN 浓度分别在暴露的第一或第二小时内迅速增加，之后达到稳定。2-MN 从血液中的消除符合开放双室模型。
动物通过吸入 2-MN 暴露，2-MN 迅速从血液中消除。在暴露期间，发现肺部对该化学物质的滞留减少。在重复暴露于 2-MN 的情况下，未观察到明显的全身性 2-MN 蓄积。
