Świercz Radosław, Wąsowicz Wojciech
Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Toxicology and Carcinogenesis).
Nofer Institute of Occupational Medicine, Łódź, Poland (Department of Biological and Environmental Monitoring).
Int J Occup Med Environ Health. 2018 Dec 20;31(6):763-770. doi: 10.13075/ijomeh.1896.01224. Epub 2018 Dec 18.
1-Methylnaphthalene (1-MN) is a constituent of polycyclic aromatic hydrocarbons, the chemicals that have become ubiquitous in the environment as result of natural and industrial process. This paper reports a study on the distribution and excretion of 1-MN in rats after single and repeated inhalation exposure to 1-MN vapor.
Male Wistar rats were exposed to 1-MN vapor at nominal concentrations of 50 mg/m3 or 200 mg/m3 in the dynamic inhalation chambers (TSE Systems Head Nose Only Exposure) for 6 h (single exposure) or 5 days (6 h/day, repeated exposure). Blood, urine and tissue samples were collected during and after the exposure. Blood, urine and tissue concentrations of 1-MN were estimated by gas chromatography using the headspace technique.
The elimination of 1-MN from blood followed an open 2-compartment model. The concentration in rat tissues was dependent on the magnitude and time of exposure. After repeated exposure, the concentration 1-MN in tissue decreased in comparison to single exposure. The elimination of 1-MN with urine after single and repeated exposure to 1-MN occurred mainly in the samples collected during the first day of collection.
1-Methylnaphthalene was rapidly eliminated from the blood and tissues of animals exposed by inhalation to 1-MN. In repeated exposure, there was probably a significant increase of 1-MN metabolism in rats exposed to low and high 1-MN doses. Under conditions of repeated 1-MN exposure, no significant systemic 1-MN accumulation could be observed. Int J Occup Med Environ Health 2018;31(6):763-770.
1-甲基萘（1-MN）是多环芳烃的一种成分，这类化学物质由于自然和工业过程已在环境中普遍存在。本文报告了一项关于大鼠单次和重复吸入1-MN蒸气后1-MN在体内的分布和排泄情况的研究。
雄性Wistar大鼠在动态吸入舱（TSE Systems头鼻单独暴露装置）中暴露于标称浓度为50 mg/m³或200 mg/m³的1-MN蒸气中6小时（单次暴露）或5天（每天6小时，重复暴露）。在暴露期间和暴露后采集血液、尿液和组织样本。采用顶空技术通过气相色谱法估算血液、尿液和组织中1-MN的浓度。
1-MN从血液中的消除遵循开放二室模型。大鼠组织中的浓度取决于暴露的程度和时间。重复暴露后，组织中1-MN的浓度与单次暴露相比有所降低。单次和重复暴露于1-MN后，1-MN随尿液的排泄主要发生在采集的第一天的样本中。
吸入暴露于1-MN的动物血液和组织中的1-甲基萘被迅速消除。在重复暴露中，暴露于低剂量和高剂量1-MN的大鼠1-MN代谢可能显著增加。在重复暴露于1-MN的条件下，未观察到明显的全身性1-MN蓄积。《国际职业医学与环境卫生杂志》2018年；31(6):763 - 770。
