Yamaguchi Hideki, Oikawa Tsukasa
Growth Factor Division, National Cancer Center Research Institute, Tokyo 104-0045, Japan.
Precursory Research for Embryonic Science and Technology, Japan Science and Technology Agency, Saitama 332-0012, Japan.
Oncotarget. 2010 Sep;1(5):320-328. doi: 10.18632/oncotarget.164.
Invadopodia are extracellular matrix (ECM)-degrading protrusions formed by invasive cancer cells. Podosomes are structures functionally similar to invadopodia that are found in oncogene-transformed fibroblasts and monocyte-derived cells, including macrophages and osteoclasts. These structures are thought to play important roles in the pericellular remodeling of ECM during cancer invasion and metastasis. Much effort has been directed toward identification of the molecular components and regulators of invadopodia/podosomes, which could be therapeutic targets in the treatment of malignant cancers. However, it remains largely unknown how these components are assembled into invadopodia/podosomes and how the assembly process is spatially and temporally regulated. This review will summarize recent progress on the molecular mechanisms of invadopodia/podosome formation, with strong emphasis on the roles of lipid rafts and phosphoinositides.
侵袭性伪足是由侵袭性癌细胞形成的降解细胞外基质（ECM）的突起。足体是在癌基因转化的成纤维细胞和单核细胞衍生细胞（包括巨噬细胞和破骨细胞）中发现的功能上与侵袭性伪足相似的结构。这些结构被认为在癌症侵袭和转移过程中细胞周围ECM重塑中起重要作用。人们已经付出了很多努力来鉴定侵袭性伪足/足体的分子成分和调节因子，它们可能是治疗恶性癌症的靶点。然而，这些成分如何组装成侵袭性伪足/足体以及组装过程如何在空间和时间上受到调节，在很大程度上仍然未知。本综述将总结侵袭性伪足/足体形成分子机制的最新进展，重点强调脂筏和磷酸肌醇的作用。
