细胞骨架在人类疾病中的作用。
Roles of the cytoskeleton in human diseases.
作者信息
Li Mengxin, Peng Li, Wang Zhenming, Liu Lijia, Cao Mengjiao, Cui Jingyao, Wu Fanzi, Yang Jing
机构信息
State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cardiology and Endodontics, West China Hospital of Stomatology, Sichuan University, 610021, Chengdu, China.
Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, 610065, Chengdu, China.
出版信息
Mol Biol Rep. 2023 Mar;50(3):2847-2856. doi: 10.1007/s11033-022-08025-5. Epub 2023 Jan 6.
Recently, researches have revealed the key roles of the cytoskeleton in the occurrence and development of multiple diseases, suggesting that targeting the cytoskeleton is a viable approach for treating numerous refractory diseases. The cytoskeleton is a highly structured and complex network composed of actin filaments, microtubules, and intermediate filaments. In normal cells, these three cytoskeleton components are highly integrated and coordinated. However, the cytoskeleton undergoes drastic remodeling in cytoskeleton-related diseases, causing changes in cell polarity, affecting the cell cycle, leading to senescent diseases, and influencing cell migration to accelerate cancer metastasis. Additionally, mutations or abnormalities in cytoskeletal proteins and their related proteins are closely associated with several congenital diseases. Therefore, this review summarizes the roles of the cytoskeleton in cytoskeleton-related diseases as well as its potential roles in disease treatment to provide insights regarding the physiological functions and pathological roles of the cytoskeleton.
最近，研究揭示了细胞骨架在多种疾病发生发展中的关键作用，这表明靶向细胞骨架是治疗众多难治性疾病的一种可行方法。细胞骨架是一个由肌动蛋白丝、微管和中间丝组成的高度结构化且复杂的网络。在正常细胞中，这三种细胞骨架成分高度整合且协调。然而，在与细胞骨架相关的疾病中，细胞骨架会发生剧烈重塑，导致细胞极性改变，影响细胞周期，引发衰老性疾病，并影响细胞迁移以加速癌症转移。此外，细胞骨架蛋白及其相关蛋白的突变或异常与几种先天性疾病密切相关。因此，本综述总结了细胞骨架在与细胞骨架相关疾病中的作用及其在疾病治疗中的潜在作用，以提供有关细胞骨架生理功能和病理作用的见解。
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